BDBM50201232 4-(2,4-dichloro-5-methoxyphenylamino)-7-(4-(dimethylamino)but-1-ynyl)-6-methoxyquinoline-3-carbonitrile::CHEMBL239140

SMILES: COc1cc(Nc2c(cnc3cc(C#CCCN(C)C)c(OC)cc23)C#N)c(Cl)cc1Cl

InChI Key: InChIKey=FQEBHBKIDZHPHV-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50201232   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50201232 (4-(2,4-dichloro-5-methoxyphenylamino)-7-(4-(dimeth...) Show SMILES COc1cc(Nc2c(cnc3cc(C#CCCN(C)C)c(OC)cc23)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C24H22Cl2N4O2/c1-30(2)8-6-5-7-15-9-20-17(10-22(15)31-3)24(16(13-27)14-28-20)29-21-12-23(32-4)19(26)11-18(21)25/h9-12,14H,6,8H2,1-4H3,(H,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.90	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of Src activity				Bioorg Med Chem Lett 17: 1358-61 (2007) Article DOI: 10.1016/j.bmcl.2006.11.077 BindingDB Entry DOI: 10.7270/Q2SJ1K7T
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Rattus norvegicus)	BDBM50201232 (4-(2,4-dichloro-5-methoxyphenylamino)-7-(4-(dimeth...) Show SMILES COc1cc(Nc2c(cnc3cc(C#CCCN(C)C)c(OC)cc23)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C24H22Cl2N4O2/c1-30(2)8-6-5-7-15-9-20-17(10-22(15)31-3)24(16(13-27)14-28-20)29-21-12-23(32-4)19(26)11-18(21)25/h9-12,14H,6,8H2,1-4H3,(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of Src in rat fibroblasts				Bioorg Med Chem Lett 17: 1358-61 (2007) Article DOI: 10.1016/j.bmcl.2006.11.077 BindingDB Entry DOI: 10.7270/Q2SJ1K7T
					More data for this Ligand-Target Pair