BindingDB PrimarySearch

BDBM50201607 CHEMBL3905835

SMILES: Cc1nccn1-c1ccc(cc1)-c1cn(CC(=O)Nc2cccc(Cl)c2Cl)nn1

InChI Key: InChIKey=XSIJYOFJNDFHGL-UHFFFAOYSA-N

Data: 5 IC50 4 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50201607
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Probable G-protein coupled receptor 142 (Homo sapiens (Human))	BDBM50201607 (CHEMBL3905835) Show SMILES Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	12	n/a	n/a	n/a	n/a
Merck& Co. Curated by ChEMBL					Assay Description Agonist activity at human GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay				ACS Med Chem Lett 7: 1107-1111 (2016) Article DOI: 10.1021/acsmedchemlett.6b00314 BindingDB Entry DOI: 10.7270/Q2ZC84V0
Merck& Co. Curated by ChEMBL					More data for this Ligand-Target Pair
Probable G-protein coupled receptor 142 (Homo sapiens (Human))	BDBM50201607 (CHEMBL3905835) Show SMILES Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	25	n/a	n/a	n/a	n/a
Merck& Co. Curated by ChEMBL					Assay Description Agonist activity at human GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay				ACS Med Chem Lett 7: 1107-1111 (2016) Article DOI: 10.1021/acsmedchemlett.6b00314 BindingDB Entry DOI: 10.7270/Q2ZC84V0
Merck& Co. Curated by ChEMBL					More data for this Ligand-Target Pair
Probable G-protein coupled receptor 142 (Mus musculus)	BDBM50201607 (CHEMBL3905835) Show SMILES Show InChI	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a
Merck& Co. Curated by ChEMBL					Assay Description Agonist activity at mouse GPR142 expressed in CHO cells measured after 30 to 60 mins by IP-One assay				ACS Med Chem Lett 7: 1107-1111 (2016) Article DOI: 10.1021/acsmedchemlett.6b00314 BindingDB Entry DOI: 10.7270/Q2ZC84V0
Merck& Co. Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50201607 (CHEMBL3905835) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co. Curated by ChEMBL					Assay Description Inhibition of CYP3A4 (unknown origin)				ACS Med Chem Lett 7: 1107-1111 (2016) Article DOI: 10.1021/acsmedchemlett.6b00314 BindingDB Entry DOI: 10.7270/Q2ZC84V0
Merck& Co. Curated by ChEMBL					More data for this Ligand-Target Pair
Probable G-protein coupled receptor 142 (Mus musculus)	BDBM50201607 (CHEMBL3905835) Show SMILES Show InChI	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	27	n/a	n/a	n/a	n/a
Merck& Co. Curated by ChEMBL					Assay Description Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 to 5 mins by Fluo-4AM dye-based FLIPR assay				ACS Med Chem Lett 7: 1107-1111 (2016) Article DOI: 10.1021/acsmedchemlett.6b00314 BindingDB Entry DOI: 10.7270/Q2ZC84V0
Merck& Co. Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM50201607 (CHEMBL3905835) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co. Curated by ChEMBL					Assay Description Inhibition of Nav1.5 (unknown origin)				ACS Med Chem Lett 7: 1107-1111 (2016) Article DOI: 10.1021/acsmedchemlett.6b00314 BindingDB Entry DOI: 10.7270/Q2ZC84V0
Merck& Co. Curated by ChEMBL					More data for this Ligand-Target Pair
Voltage-gated calcium channel (Homo sapiens (Human))	BDBM50201607 (CHEMBL3905835) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co. Curated by ChEMBL					Assay Description Inhibition of Cav1.2 (unknown origin)				ACS Med Chem Lett 7: 1107-1111 (2016) Article DOI: 10.1021/acsmedchemlett.6b00314 BindingDB Entry DOI: 10.7270/Q2ZC84V0
Merck& Co. Curated by ChEMBL					More data for this Ligand-Target Pair
1,3-beta-glucan synthase component GLS2 (Saccharomyces cerevisiae)	BDBM50201607 (CHEMBL3905835) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co. Curated by ChEMBL					Assay Description Inhibition of human ERG				ACS Med Chem Lett 7: 1107-1111 (2016) Article DOI: 10.1021/acsmedchemlett.6b00314 BindingDB Entry DOI: 10.7270/Q2ZC84V0
Merck& Co. Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Homo sapiens (Human))	BDBM50201607 (CHEMBL3905835) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co. Curated by ChEMBL					Assay Description Inhibition of CYP2D6 (unknown origin)				ACS Med Chem Lett 7: 1107-1111 (2016) Article DOI: 10.1021/acsmedchemlett.6b00314 BindingDB Entry DOI: 10.7270/Q2ZC84V0
Merck& Co. Curated by ChEMBL					More data for this Ligand-Target Pair