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SMILES: CCOc1cccc2C(=O)N(Cc3cc(Cl)ccc3NC(=O)c3ccccn3)C(=O)c12

InChI Key: InChIKey=GYFJSDOHDHLNJB-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50202144   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50202144
PNG
(CHEMBL395644 | N-(4-chloro-2-((4-ethoxy-1,3-dioxoi...)
Show SMILES CCOc1cccc2C(=O)N(Cc3cc(Cl)ccc3NC(=O)c3ccccn3)C(=O)c12
Show InChI InChI=1S/C23H18ClN3O4/c1-2-31-19-8-5-6-16-20(19)23(30)27(22(16)29)13-14-12-15(24)9-10-17(14)26-21(28)18-7-3-4-11-25-18/h3-12H,2,13H2,1H3,(H,26,28)
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Similars
Article
PubMed
n/an/an/an/a 280n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Activity at human mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assay

Bioorg Med Chem Lett 17: 1386-91 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.081
BindingDB Entry DOI: 10.7270/Q22V2GXH
More data for this
Ligand-Target Pair