BDBM50203486 2-(4-(4-(2-isopropoxyphenyl)piperazin-1-yl)cyclohexyl)-2H-pyrrolo[3,4-c]pyridine-1,3-dione::CHEMBL243229
SMILES: CC(C)Oc1ccccc1N1CCN(CC1)C1CCC(CC1)N1C(=O)c2ccncc2C1=O
InChI Key: InChIKey=TVYZZMXYQYLCHO-UHFFFAOYSA-N
Data: 3 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Alpha-1A adrenergic receptor (Homo sapiens (Human)) | BDBM50203486 (2-(4-(4-(2-isopropoxyphenyl)piperazin-1-yl)cyclohe...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development LLC Curated by ChEMBL | Assay Description Displacement of [125]HEAT from human adrenergic alpha1a receptor expressed in CHO cells | Bioorg Med Chem Lett 17: 1646-50 (2007) Article DOI: 10.1016/j.bmcl.2006.12.111 BindingDB Entry DOI: 10.7270/Q2PG1RC2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1D adrenergic receptor (Homo sapiens (Human)) | BDBM50203486 (2-(4-(4-(2-isopropoxyphenyl)piperazin-1-yl)cyclohe...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development LLC Curated by ChEMBL | Assay Description Displacement of [125]HEAT from human adrenergic alpha1d receptor expressed in CHO cells | Bioorg Med Chem Lett 17: 1646-50 (2007) Article DOI: 10.1016/j.bmcl.2006.12.111 BindingDB Entry DOI: 10.7270/Q2PG1RC2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adrenergic alpha1B (Homo sapiens (Human)) | BDBM50203486 (2-(4-(4-(2-isopropoxyphenyl)piperazin-1-yl)cyclohe...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 22.4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development LLC Curated by ChEMBL | Assay Description Displacement of [125]HEAT from human adrenergic alpha1b receptor expressed in CHO cells | Bioorg Med Chem Lett 17: 1646-50 (2007) Article DOI: 10.1016/j.bmcl.2006.12.111 BindingDB Entry DOI: 10.7270/Q2PG1RC2 | |||||||||||
More data for this Ligand-Target Pair |