BDBM50203524 (6S,7S)-N-hydroxy-6-{[4-(2-methylphenyl)piperazin-1-yl]carbonyl}-5-azaspiro[2.5]octane-7-carboxamide::CHEMBL220501

SMILES: Cc1ccccc1N1CCN(CC1)C(=O)[C@H]1NCC2(CC2)C[C@@H]1C(=O)NO

InChI Key: InChIKey=SMNLJWDKCNVQNU-RDJZCZTQSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50203524   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50203524 ((6S,7S)-N-hydroxy-6-{[4-(2-methylphenyl)piperazin-...) Show SMILES Cc1ccccc1N1CCN(CC1)C(=O)[C@H]1NCC2(CC2)C[C@@H]1C(=O)NO Show InChI InChI=1S/C20H28N4O3/c1-14-4-2-3-5-16(14)23-8-10-24(11-9-23)19(26)17-15(18(25)22-27)12-20(6-7-20)13-21-17/h2-5,15,17,21,27H,6-13H2,1H3,(H,22,25)/t15-,17-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation Curated by ChEMBL					Assay Description Inhibition of MMP9				J Med Chem 50: 603-6 (2007) Article DOI: 10.1021/jm061344o BindingDB Entry DOI: 10.7270/Q2JQ10P5
					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50203524 ((6S,7S)-N-hydroxy-6-{[4-(2-methylphenyl)piperazin-...) Show SMILES Cc1ccccc1N1CCN(CC1)C(=O)[C@H]1NCC2(CC2)C[C@@H]1C(=O)NO Show InChI InChI=1S/C20H28N4O3/c1-14-4-2-3-5-16(14)23-8-10-24(11-9-23)19(26)17-15(18(25)22-27)12-20(6-7-20)13-21-17/h2-5,15,17,21,27H,6-13H2,1H3,(H,22,25)/t15-,17-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation Curated by ChEMBL					Assay Description Inhibition of MMP3				J Med Chem 50: 603-6 (2007) Article DOI: 10.1021/jm061344o BindingDB Entry DOI: 10.7270/Q2JQ10P5
					More data for this Ligand-Target Pair
Interstitial collagenase (Homo sapiens (Human))	BDBM50203524 ((6S,7S)-N-hydroxy-6-{[4-(2-methylphenyl)piperazin-...) Show SMILES Cc1ccccc1N1CCN(CC1)C(=O)[C@H]1NCC2(CC2)C[C@@H]1C(=O)NO Show InChI InChI=1S/C20H28N4O3/c1-14-4-2-3-5-16(14)23-8-10-24(11-9-23)19(26)17-15(18(25)22-27)12-20(6-7-20)13-21-17/h2-5,15,17,21,27H,6-13H2,1H3,(H,22,25)/t15-,17-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation Curated by ChEMBL					Assay Description Inhibition of MMP1				J Med Chem 50: 603-6 (2007) Article DOI: 10.1021/jm061344o BindingDB Entry DOI: 10.7270/Q2JQ10P5
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) (Homo sapiens (Human))	BDBM50203524 ((6S,7S)-N-hydroxy-6-{[4-(2-methylphenyl)piperazin-...) Show SMILES Cc1ccccc1N1CCN(CC1)C(=O)[C@H]1NCC2(CC2)C[C@@H]1C(=O)NO Show InChI InChI=1S/C20H28N4O3/c1-14-4-2-3-5-16(14)23-8-10-24(11-9-23)19(26)17-15(18(25)22-27)12-20(6-7-20)13-21-17/h2-5,15,17,21,27H,6-13H2,1H3,(H,22,25)/t15-,17-/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation Curated by ChEMBL					Assay Description Inhibition of ADAM10				J Med Chem 50: 603-6 (2007) Article DOI: 10.1021/jm061344o BindingDB Entry DOI: 10.7270/Q2JQ10P5
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50203524 ((6S,7S)-N-hydroxy-6-{[4-(2-methylphenyl)piperazin-...) Show SMILES Cc1ccccc1N1CCN(CC1)C(=O)[C@H]1NCC2(CC2)C[C@@H]1C(=O)NO Show InChI InChI=1S/C20H28N4O3/c1-14-4-2-3-5-16(14)23-8-10-24(11-9-23)19(26)17-15(18(25)22-27)12-20(6-7-20)13-21-17/h2-5,15,17,21,27H,6-13H2,1H3,(H,22,25)/t15-,17-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation Curated by ChEMBL					Assay Description Inhibition of MMP2				J Med Chem 50: 603-6 (2007) Article DOI: 10.1021/jm061344o BindingDB Entry DOI: 10.7270/Q2JQ10P5
					More data for this Ligand-Target Pair