BDBM50204888 CHEMBL223695::[4-(3-fluorobenzyl)-piperidine-1-yl]-(6-hydroxy-1H-indole-2-yl)-methanone

SMILES: Oc1ccc2cc([nH]c2c1)C(=O)N1CCC(Cc2cccc(F)c2)CC1

InChI Key: InChIKey=JFPXKCUDHUXMED-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50204888   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50204888 (CHEMBL223695 | [4-(3-fluorobenzyl)-piperidine-1-yl...) Show SMILES Oc1ccc2cc([nH]c2c1)C(=O)N1CCC(Cc2cccc(F)c2)CC1 Show InChI InChI=1S/C21H21FN2O2/c22-17-3-1-2-15(11-17)10-14-6-8-24(9-7-14)21(26)20-12-16-4-5-18(25)13-19(16)23-20/h1-5,11-14,23,25H,6-10H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50204888 (CHEMBL223695 | [4-(3-fluorobenzyl)-piperidine-1-yl...) Show SMILES Oc1ccc2cc([nH]c2c1)C(=O)N1CCC(Cc2cccc(F)c2)CC1 Show InChI InChI=1S/C21H21FN2O2/c22-17-3-1-2-15(11-17)10-14-6-8-24(9-7-14)21(26)20-12-16-4-5-18(25)13-19(16)23-20/h1-5,11-14,23,25H,6-10H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair