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SMILES: COc1c2C(=O)N3CCNC[C@H]3c2ccc1Cl

InChI Key: InChIKey=JGMDYLOFCDBBNK-VIFPVBQESA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50205872   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-hydroxytryptamine receptor 2B (Homo sapiens (Human))	BDBM50205872 ((R)-8-chloro-7-methoxy-1,3,4,10b-tetrahydropyrazin...) Show SMILES COc1c2C(=O)N3CCNC[C@H]3c2ccc1Cl Show InChI InChI=1S/C12H13ClN2O2/c1-17-11-8(13)3-2-7-9-6-14-4-5-15(9)12(16)10(7)11/h2-3,9,14H,4-6H2,1H3/t9-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	86	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells				J Med Chem 50: 1365-79 (2007) Article DOI: 10.1021/jm0612968 BindingDB Entry DOI: 10.7270/Q2XP74M8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50205872 ((R)-8-chloro-7-methoxy-1,3,4,10b-tetrahydropyrazin...) Show SMILES COc1c2C(=O)N3CCNC[C@H]3c2ccc1Cl Show InChI InChI=1S/C12H13ClN2O2/c1-17-11-8(13)3-2-7-9-6-14-4-5-15(9)12(16)10(7)11/h2-3,9,14H,4-6H2,1H3/t9-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	176	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Displacement of [125I]DOI from human recombinant 5HT2C expressed in HEK293E cells				J Med Chem 50: 1365-79 (2007) Article DOI: 10.1021/jm0612968 BindingDB Entry DOI: 10.7270/Q2XP74M8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50205872 ((R)-8-chloro-7-methoxy-1,3,4,10b-tetrahydropyrazin...) Show SMILES COc1c2C(=O)N3CCNC[C@H]3c2ccc1Cl Show InChI InChI=1S/C12H13ClN2O2/c1-17-11-8(13)3-2-7-9-6-14-4-5-15(9)12(16)10(7)11/h2-3,9,14H,4-6H2,1H3/t9-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	813	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Displacement of [125I]DOI from human recombinant 5HT2A expressed in HEK293E cells				J Med Chem 50: 1365-79 (2007) Article DOI: 10.1021/jm0612968 BindingDB Entry DOI: 10.7270/Q2XP74M8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50205872 ((R)-8-chloro-7-methoxy-1,3,4,10b-tetrahydropyrazin...) Show SMILES COc1c2C(=O)N3CCNC[C@H]3c2ccc1Cl Show InChI InChI=1S/C12H13ClN2O2/c1-17-11-8(13)3-2-7-9-6-14-4-5-15(9)12(16)10(7)11/h2-3,9,14H,4-6H2,1H3/t9-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	12	n/a	n/a	n/a	n/a
Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay				J Med Chem 50: 1365-79 (2007) Article DOI: 10.1021/jm0612968 BindingDB Entry DOI: 10.7270/Q2XP74M8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2B (Homo sapiens (Human))	BDBM50205872 ((R)-8-chloro-7-methoxy-1,3,4,10b-tetrahydropyrazin...) Show SMILES COc1c2C(=O)N3CCNC[C@H]3c2ccc1Cl Show InChI InChI=1S/C12H13ClN2O2/c1-17-11-8(13)3-2-7-9-6-14-4-5-15(9)12(16)10(7)11/h2-3,9,14H,4-6H2,1H3/t9-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	28	n/a	n/a	n/a	n/a
Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay				J Med Chem 50: 1365-79 (2007) Article DOI: 10.1021/jm0612968 BindingDB Entry DOI: 10.7270/Q2XP74M8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50205872 ((R)-8-chloro-7-methoxy-1,3,4,10b-tetrahydropyrazin...) Show SMILES COc1c2C(=O)N3CCNC[C@H]3c2ccc1Cl Show InChI InChI=1S/C12H13ClN2O2/c1-17-11-8(13)3-2-7-9-6-14-4-5-15(9)12(16)10(7)11/h2-3,9,14H,4-6H2,1H3/t9-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	872	n/a	n/a	n/a	n/a
Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay				J Med Chem 50: 1365-79 (2007) Article DOI: 10.1021/jm0612968 BindingDB Entry DOI: 10.7270/Q2XP74M8
					More data for this Ligand-Target Pair