BDBM50206043 ((2S,4S)-4-(4-(5-nitropyridin-2-yl)piperazin-1-yl)pyrrolidin-2-yl)(thiazolidin-3-yl)methanone::CHEMBL399610
SMILES: [O-][N+](=O)c1ccc(nc1)N1CCN(CC1)[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1
InChI Key: InChIKey=MAZMJZPWHREVQB-GJZGRUSLSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dipeptidyl peptidase 4 (Homo sapiens (Human)) | BDBM50206043![]() (((2S,4S)-4-(4-(5-nitropyridin-2-yl)piperazin-1-yl)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.920 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Pharma Corporation Curated by ChEMBL | Assay Description Inhibition of DPP4 in human plasma by fluorescence assay | Bioorg Med Chem Lett 17: 2618-21 (2007) Article DOI: 10.1016/j.bmcl.2007.01.110 BindingDB Entry DOI: 10.7270/Q29023GP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dipeptidyl peptidase 4 (Homo sapiens (Human)) | BDBM50206043![]() (((2S,4S)-4-(4-(5-nitropyridin-2-yl)piperazin-1-yl)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.920 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Tanabe Pharma Corporation Curated by ChEMBL | Assay Description Inhibition of human DPP4 using Gly-Pro-MCA as substrate after 60 mins by fluorometry | Bioorg Med Chem 20: 5033-41 (2012) Article DOI: 10.1016/j.bmc.2012.06.033 BindingDB Entry DOI: 10.7270/Q20Z74B2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dipeptidyl peptidase IV (Rattus norvegicus (rat)) | BDBM50206043![]() (((2S,4S)-4-(4-(5-nitropyridin-2-yl)piperazin-1-yl)...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Tanabe Pharma Corporation Curated by ChEMBL | Assay Description Inhibition of rat DPP4 using Gly-Pro-MCA as substrate after 60 mins by fluorometry | Bioorg Med Chem 20: 5033-41 (2012) Article DOI: 10.1016/j.bmc.2012.06.033 BindingDB Entry DOI: 10.7270/Q20Z74B2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dipeptidyl peptidase IV (Rattus norvegicus (rat)) | BDBM50206043![]() (((2S,4S)-4-(4-(5-nitropyridin-2-yl)piperazin-1-yl)...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Pharma Corporation Curated by ChEMBL | Assay Description Inhibition of DPP4 in rat plasma by fluorescence assay | Bioorg Med Chem Lett 17: 2618-21 (2007) Article DOI: 10.1016/j.bmcl.2007.01.110 BindingDB Entry DOI: 10.7270/Q29023GP | |||||||||||
More data for this Ligand-Target Pair |