BDBM50206448 CHEMBL3944542

SMILES: CC(C)C1=C\C(=N\OC(=O)c2ccccc2C)C(C)=CC1=O

InChI Key: InChIKey=CMOJHDQJJPIVEC-MNDPQUGUSA-N

Data: 1 IC50  5 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50206448   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM50206448 (CHEMBL3944542) Show SMILES CC(C)C1=C\C(=N\OC(=O)c2ccccc2C)C(C)=CC1=O |c:19,t:3| Show InChI InChI=1S/C18H19NO3/c1-11(2)15-10-16(13(4)9-17(15)20)19-22-18(21)14-8-6-5-7-12(14)3/h5-11H,1-4H3/b19-16-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.94E+4	n/a	n/a	n/a	n/a	n/a	n/a
Peking University Curated by ChEMBL					Assay Description Inhibition of 5-FAM-DPPLHSpTAI-OH binding to PLK1 polo-box domain (unknown origin) expressed in Escherichia coli Rosetta (DE3) after 1 hr by fluoresc...				Eur J Med Chem 124: 229-236 (2016) Article DOI: 10.1016/j.ejmech.2016.08.043 BindingDB Entry DOI: 10.7270/Q22F7QFW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM50206448 (CHEMBL3944542) Show SMILES CC(C)C1=C\C(=N\OC(=O)c2ccccc2C)C(C)=CC1=O |c:19,t:3| Show InChI InChI=1S/C18H19NO3/c1-11(2)15-10-16(13(4)9-17(15)20)19-22-18(21)14-8-6-5-7-12(14)3/h5-11H,1-4H3/b19-16-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	1.05E+4	n/a	n/a	n/a	n/a	n/a
Peking University Curated by ChEMBL					Assay Description Binding affinity to NT-647 labeled PLK1 polo-box domain (unknown origin) expressed in Escherichia coli Rosetta (DE3) by microscale thermophoresis bas...				Eur J Med Chem 124: 229-236 (2016) Article DOI: 10.1016/j.ejmech.2016.08.043 BindingDB Entry DOI: 10.7270/Q22F7QFW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM50206448 (CHEMBL3944542) Show SMILES CC(C)C1=C\C(=N\OC(=O)c2ccccc2C)C(C)=CC1=O |c:19,t:3| Show InChI InChI=1S/C18H19NO3/c1-11(2)15-10-16(13(4)9-17(15)20)19-22-18(21)14-8-6-5-7-12(14)3/h5-11H,1-4H3/b19-16-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	4.08E+5	n/a	n/a	n/a	n/a	n/a
Peking University Curated by ChEMBL					Assay Description Binding affinity to GST-tagged PLK1 PBD W414A mutant (unknown origin) by NT-647 dye-based microscale thermophoresis analysis				J Med Chem 59: 7089-96 (2016) Article DOI: 10.1021/acs.jmedchem.6b00261
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK2 (Homo sapiens (Human))	BDBM50206448 (CHEMBL3944542) Show SMILES CC(C)C1=C\C(=N\OC(=O)c2ccccc2C)C(C)=CC1=O |c:19,t:3| Show InChI InChI=1S/C18H19NO3/c1-11(2)15-10-16(13(4)9-17(15)20)19-22-18(21)14-8-6-5-7-12(14)3/h5-11H,1-4H3/b19-16-	PDB NCI pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	8.73E+4	n/a	n/a	n/a	n/a	n/a
Peking University Curated by ChEMBL					Assay Description Binding affinity to GST-tagged PLK2 PBD (355 to 685 residues) (unknown origin) by NT-647 dye-based microscale thermophoresis analysis				J Med Chem 59: 7089-96 (2016) Article DOI: 10.1021/acs.jmedchem.6b00261
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK3 (Homo sapiens (Human))	BDBM50206448 (CHEMBL3944542) Show SMILES CC(C)C1=C\C(=N\OC(=O)c2ccccc2C)C(C)=CC1=O |c:19,t:3| Show InChI InChI=1S/C18H19NO3/c1-11(2)15-10-16(13(4)9-17(15)20)19-22-18(21)14-8-6-5-7-12(14)3/h5-11H,1-4H3/b19-16-	PDB NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	2.96E+5	n/a	n/a	n/a	n/a	n/a
Peking University Curated by ChEMBL					Assay Description Binding affinity to GST-tagged PLK3 PBD (335 to 646 residues) (unknown origin) by NT-647 dye-based microscale thermophoresis analysis				J Med Chem 59: 7089-96 (2016) Article DOI: 10.1021/acs.jmedchem.6b00261
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM50206448 (CHEMBL3944542) Show SMILES CC(C)C1=C\C(=N\OC(=O)c2ccccc2C)C(C)=CC1=O |c:19,t:3| Show InChI InChI=1S/C18H19NO3/c1-11(2)15-10-16(13(4)9-17(15)20)19-22-18(21)14-8-6-5-7-12(14)3/h5-11H,1-4H3/b19-16-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	3.57E+4	n/a	n/a	n/a	n/a	n/a
Peking University Curated by ChEMBL					Assay Description Binding affinity to GST-tagged PLK1 PBD (327 to 603 residues) (unknown origin) by NT-647 dye-based microscale thermophoresis analysis				J Med Chem 59: 7089-96 (2016) Article DOI: 10.1021/acs.jmedchem.6b00261
					More data for this Ligand-Target Pair