BDBM50207312 CHEMBL3954951

SMILES: CN(C)C(=O)Cc1c(nc2ccc(F)cn12)-c1ccc(F)cc1

InChI Key: InChIKey=ZGAAIHOMEBTXHT-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50207312   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
GABA-A receptor; alpha-1/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50207312 (CHEMBL3954951) Show SMILES CN(C)C(=O)Cc1c(nc2ccc(F)cn12)-c1ccc(F)cc1 Show InChI InChI=1S/C17H15F2N3O/c1-21(2)16(23)9-14-17(11-3-5-12(18)6-4-11)20-15-8-7-13(19)10-22(14)15/h3-8,10H,9H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	408	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Positive allosteric modulation of human recombinant GABA-A receptor alpha1beta2gamma2 expressed in HEK293 cells assessed as potentiation of of GABA i...				Eur J Med Chem 124: 456-467 (2016) Article DOI: 10.1016/j.ejmech.2016.08.059 BindingDB Entry DOI: 10.7270/Q22B911Z
					More data for this Ligand-Target Pair