BDBM50207593 (S)-1-(2-AMINO-2-CARBOXYETHYL)-3(2-CARBOXYTHIOPHENE-3-YL-METHYL)-5-METHYLPYRIMIDINE-2,4-DIONE::(S)-1-(2-amino-2-carboxyethyl)-3-(2-carboxythiophene-3-ylmethyl)-5-methylpyrimidine-2,4-dione::CHEMBL373428

SMILES: Cc1cn(C[C@H](N)C(O)=O)c(=O)n(Cc2ccsc2C(O)=O)c1=O

InChI Key: InChIKey=ZTAZUCRXCRXNSU-VIFPVBQESA-N

Data: 1 KI  2 IC50  1 Kd

PDB links: 2 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50207593   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glutamate receptor ionotropic, kainate (Rattus norvegicus)	BDBM50207593 ((S)-1-(2-AMINO-2-CARBOXYETHYL)-3(2-CARBOXYTHIOPHEN...) Show SMILES Cc1cn(C[C@H](N)C(O)=O)c(=O)n(Cc2ccsc2C(O)=O)c1=O Show InChI InChI=1S/C14H15N3O6S/c1-7-4-16(6-9(15)12(19)20)14(23)17(11(7)18)5-8-2-3-24-10(8)13(21)22/h2-4,9H,5-6,15H2,1H3,(H,19,20)(H,21,22)/t9-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	23	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Displacement of [3H]SYM2081 from rat GluK3 expressed in Sf9 cells				J Med Chem 54: 4793-805 (2011) Article DOI: 10.1021/jm2004078 BindingDB Entry DOI: 10.7270/Q2RR1ZM2
					More data for this Ligand-Target Pair
GRIA2 (Homo sapiens (Human))	BDBM50207593 ((S)-1-(2-AMINO-2-CARBOXYETHYL)-3(2-CARBOXYTHIOPHEN...) Show SMILES Cc1cn(C[C@H](N)C(O)=O)c(=O)n(Cc2ccsc2C(O)=O)c1=O Show InChI InChI=1S/C14H15N3O6S/c1-7-4-16(6-9(15)12(19)20)14(23)17(11(7)18)5-8-2-3-24-10(8)13(21)22/h2-4,9H,5-6,15H2,1H3,(H,19,20)(H,21,22)/t9-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GLUA2-AMPA receptor expressed in HEK293 cells assessed as inhibition of glutamate-stimulated calcium influx ...				J Med Chem 50: 1558-70 (2007) Article DOI: 10.1021/jm061041u BindingDB Entry DOI: 10.7270/Q2X34Z8Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2 (Homo sapiens (Human))	BDBM50207593 ((S)-1-(2-AMINO-2-CARBOXYETHYL)-3(2-CARBOXYTHIOPHEN...) Show SMILES Cc1cn(C[C@H](N)C(O)=O)c(=O)n(Cc2ccsc2C(O)=O)c1=O Show InChI InChI=1S/C14H15N3O6S/c1-7-4-16(6-9(15)12(19)20)14(23)17(11(7)18)5-8-2-3-24-10(8)13(21)22/h2-4,9H,5-6,15H2,1H3,(H,19,20)(H,21,22)/t9-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GLUK6 expressed in HEK293 cells assessed as inhibition of glutamate-stimulated calcium influx by FLIPR assay				J Med Chem 50: 1558-70 (2007) Article DOI: 10.1021/jm061041u BindingDB Entry DOI: 10.7270/Q2X34Z8Q
					More data for this Ligand-Target Pair				3D Structure (crystal)
Glutamate receptor ionotropic, kainate 1 (RAT)	BDBM50207593 ((S)-1-(2-AMINO-2-CARBOXYETHYL)-3(2-CARBOXYTHIOPHEN...) Show SMILES Cc1cn(C[C@H](N)C(O)=O)c(=O)n(Cc2ccsc2C(O)=O)c1=O Show InChI InChI=1S/C14H15N3O6S/c1-7-4-16(6-9(15)12(19)20)14(23)17(11(7)18)5-8-2-3-24-10(8)13(21)22/h2-4,9H,5-6,15H2,1H3,(H,19,20)(H,21,22)/t9-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Activity at native GLUK5 kainate receptor assessed as antagonism of kainite-induced depolarization of neonatal anaesthetised rat dorsal root fibres				J Med Chem 50: 1558-70 (2007) Article DOI: 10.1021/jm061041u BindingDB Entry DOI: 10.7270/Q2X34Z8Q
					More data for this Ligand-Target Pair				3D Structure (crystal)