BDBM50210098 6-(4,5-dichloro-2-methoxybenzyl)-4-(4-chlorophenylsulfonyl)-1,4-diazepane-2,5-dione::CHEMBL428927

SMILES: COc1cc(Cl)c(Cl)cc1CC1CNC(=O)CN(C1=O)S(=O)(=O)c1ccc(Cl)cc1

InChI Key: InChIKey=NYUDYXREZPBFKF-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50210098   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Chymase (Homo sapiens (Human))	BDBM50210098 (6-(4,5-dichloro-2-methoxybenzyl)-4-(4-chlorophenyl...) Show SMILES COc1cc(Cl)c(Cl)cc1CC1CNC(=O)CN(C1=O)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C19H17Cl3N2O5S/c1-29-17-8-16(22)15(21)7-11(17)6-12-9-23-18(25)10-24(19(12)26)30(27,28)14-4-2-13(20)3-5-14/h2-5,7-8,12H,6,9-10H2,1H3,(H,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Asubio Pharma Co., Ltd Curated by ChEMBL					Assay Description Inhibition of human recombinant chymase				Bioorg Med Chem Lett 17: 3431-4 (2007) Article DOI: 10.1016/j.bmcl.2007.03.038 BindingDB Entry DOI: 10.7270/Q2G160H9
					More data for this Ligand-Target Pair