BDBM50210119 4-(4-chlorophenylsulfonyl)-6-(pyridin-3-ylmethyl)-1,4-diazepane-2,5-dione::CHEMBL245739

SMILES: Clc1ccc(cc1)S(=O)(=O)N1CC(=O)NCC(Cc2cccnc2)C1=O

InChI Key: InChIKey=QBAPAIGRPDIDJK-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50210119   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Chymase (Homo sapiens (Human))	BDBM50210119 (4-(4-chlorophenylsulfonyl)-6-(pyridin-3-ylmethyl)-...) Show SMILES Clc1ccc(cc1)S(=O)(=O)N1CC(=O)NCC(Cc2cccnc2)C1=O Show InChI InChI=1S/C17H16ClN3O4S/c18-14-3-5-15(6-4-14)26(24,25)21-11-16(22)20-10-13(17(21)23)8-12-2-1-7-19-9-12/h1-7,9,13H,8,10-11H2,(H,20,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Asubio Pharma Co., Ltd Curated by ChEMBL					Assay Description Inhibition of human recombinant chymase				Bioorg Med Chem Lett 17: 3431-4 (2007) Article DOI: 10.1016/j.bmcl.2007.03.038 BindingDB Entry DOI: 10.7270/Q2G160H9
					More data for this Ligand-Target Pair