Found 5 hits for monomerid = 50211431 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Mitogen-activated protein kinase 9
(Homo sapiens (Human)) | BDBM50211431
(4-(5-cyano-4-(6-fluoro-1H-indol-3-yl)pyrimidin-2-y...)Show SMILES CCNC(=O)N1CCC(CC1)Nc1ncc(C#N)c(n1)-c1c[nH]c2cc(F)ccc12 Show InChI InChI=1S/C21H22FN7O/c1-2-24-21(30)29-7-5-15(6-8-29)27-20-26-11-13(10-23)19(28-20)17-12-25-18-9-14(22)3-4-16(17)18/h3-4,9,11-12,15,25H,2,5-8H2,1H3,(H,24,30)(H,26,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 67 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB
Curated by ChEMBL
| Assay Description Inhibition of JNK2 |
Bioorg Med Chem Lett 17: 3463-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.078 BindingDB Entry DOI: 10.7270/Q2959H7W |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 8
(Homo sapiens (Human)) | BDBM50211431
(4-(5-cyano-4-(6-fluoro-1H-indol-3-yl)pyrimidin-2-y...)Show SMILES CCNC(=O)N1CCC(CC1)Nc1ncc(C#N)c(n1)-c1c[nH]c2cc(F)ccc12 Show InChI InChI=1S/C21H22FN7O/c1-2-24-21(30)29-7-5-15(6-8-29)27-20-26-11-13(10-23)19(28-20)17-12-25-18-9-14(22)3-4-16(17)18/h3-4,9,11-12,15,25H,2,5-8H2,1H3,(H,24,30)(H,26,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 92 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB
Curated by ChEMBL
| Assay Description Inhibition of JNK1 |
Bioorg Med Chem Lett 17: 3463-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.078 BindingDB Entry DOI: 10.7270/Q2959H7W |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 10
(Homo sapiens (Human)) | BDBM50211431
(4-(5-cyano-4-(6-fluoro-1H-indol-3-yl)pyrimidin-2-y...)Show SMILES CCNC(=O)N1CCC(CC1)Nc1ncc(C#N)c(n1)-c1c[nH]c2cc(F)ccc12 Show InChI InChI=1S/C21H22FN7O/c1-2-24-21(30)29-7-5-15(6-8-29)27-20-26-11-13(10-23)19(28-20)17-12-25-18-9-14(22)3-4-16(17)18/h3-4,9,11-12,15,25H,2,5-8H2,1H3,(H,24,30)(H,26,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 412 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB
Curated by ChEMBL
| Assay Description Inhibition of JNK3 |
Bioorg Med Chem Lett 17: 3463-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.078 BindingDB Entry DOI: 10.7270/Q2959H7W |
More data for this Ligand-Target Pair | |
Transcription factor Jun
(Homo sapiens (Human)) | BDBM50211431
(4-(5-cyano-4-(6-fluoro-1H-indol-3-yl)pyrimidin-2-y...)Show SMILES CCNC(=O)N1CCC(CC1)Nc1ncc(C#N)c(n1)-c1c[nH]c2cc(F)ccc12 Show InChI InChI=1S/C21H22FN7O/c1-2-24-21(30)29-7-5-15(6-8-29)27-20-26-11-13(10-23)19(28-20)17-12-25-18-9-14(22)3-4-16(17)18/h3-4,9,11-12,15,25H,2,5-8H2,1H3,(H,24,30)(H,26,27,28) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB
Curated by ChEMBL
| Assay Description Inhibition of cJun translocation in IL1beta-stimulated A549 cells |
Bioorg Med Chem Lett 17: 3463-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.078 BindingDB Entry DOI: 10.7270/Q2959H7W |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50211431
(4-(5-cyano-4-(6-fluoro-1H-indol-3-yl)pyrimidin-2-y...)Show SMILES CCNC(=O)N1CCC(CC1)Nc1ncc(C#N)c(n1)-c1c[nH]c2cc(F)ccc12 Show InChI InChI=1S/C21H22FN7O/c1-2-24-21(30)29-7-5-15(6-8-29)27-20-26-11-13(10-23)19(28-20)17-12-25-18-9-14(22)3-4-16(17)18/h3-4,9,11-12,15,25H,2,5-8H2,1H3,(H,24,30)(H,26,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 412 | n/a | n/a | n/a | n/a | n/a | n/a |
UCB
Curated by ChEMBL
| Assay Description Inhibition of CDK2 by IMAP technology |
Bioorg Med Chem Lett 17: 3463-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.078 BindingDB Entry DOI: 10.7270/Q2959H7W |
More data for this Ligand-Target Pair | |