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SMILES: COc1cc-2c(Cc3c(n[nH]c-23)-c2ccc(cc2)-c2ccc(O)c(F)c2)cc1C(=O)NCc1ccccn1

InChI Key: InChIKey=GEPIJNOQIMTAMV-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50212506   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM50212506
PNG
(3-(3'-fluoro-4'-hydroxy-biphenyl-4-yl)-7-methoxy-1...)
Show SMILES COc1cc-2c(Cc3c(n[nH]c-23)-c2ccc(cc2)-c2ccc(O)c(F)c2)cc1C(=O)NCc1ccccn1
Show InChI InChI=1S/C30H23FN4O3/c1-38-27-15-22-20(12-23(27)30(37)33-16-21-4-2-3-11-32-21)13-24-28(34-35-29(22)24)18-7-5-17(6-8-18)19-9-10-26(36)25(31)14-19/h2-12,14-15,36H,13,16H2,1H3,(H,33,37)(H,34,35)
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n/an/a 27n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of recombinant CHK-mediated Cdc25C phosphorylation after 30 mins

Bioorg Med Chem Lett 17: 3618-23 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.055
BindingDB Entry DOI: 10.7270/Q2DR2V6Q
More data for this
Ligand-Target Pair