BDBM50214079 1-(3-chlorophenyl)-5-(4-chlorophenyl)-6-methyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one::CHEMBL399309

SMILES: Cc1nc2n(ncc2c(=O)n1-c1ccc(Cl)cc1)-c1cccc(Cl)c1

InChI Key: InChIKey=RCVJKKYLQNAHPL-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50214079   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50214079 (1-(3-chlorophenyl)-5-(4-chlorophenyl)-6-methyl-1H-...) Show SMILES Cc1nc2n(ncc2c(=O)n1-c1ccc(Cl)cc1)-c1cccc(Cl)c1 Show InChI InChI=1S/C18H12Cl2N4O/c1-11-22-17-16(10-21-24(17)15-4-2-3-13(20)9-15)18(25)23(11)14-7-5-12(19)6-8-14/h2-10H,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human mGluR5 receptor expressed in 132N1 cells assessed as inhibition of glutamate-induced calcium flux by FLIPR assay				Bioorg Med Chem Lett 17: 4303-7 (2007) Article DOI: 10.1016/j.bmcl.2007.05.028 BindingDB Entry DOI: 10.7270/Q2445M5T
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50214079 (1-(3-chlorophenyl)-5-(4-chlorophenyl)-6-methyl-1H-...) Show SMILES Cc1nc2n(ncc2c(=O)n1-c1ccc(Cl)cc1)-c1cccc(Cl)c1 Show InChI InChI=1S/C18H12Cl2N4O/c1-11-22-17-16(10-21-24(17)15-4-2-3-13(20)9-15)18(25)23(11)14-7-5-12(19)6-8-14/h2-10H,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	220	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human mGluR1 receptor expressed in 132N1 cells assessed as inhibition of glutamate-induced calcium flux by FLIPR assay				Bioorg Med Chem Lett 17: 4303-7 (2007) Article DOI: 10.1016/j.bmcl.2007.05.028 BindingDB Entry DOI: 10.7270/Q2445M5T
					More data for this Ligand-Target Pair