BDBM50215419 CHEMBL243537::N-((1-amino-4-oxo-3,4-dihydrophthalazin-6-yl)methyl)-2-(6-(3-aminophenyl)-5-chloro-3-(cyclobutylamino)-2-oxopyrazin-1(2H)-yl)acetamide

SMILES: Nc1cccc(c1)-c1c(Cl)nc(NC2CCC2)c(=O)n1CC(=O)NCc1ccc2c(N)n[nH]c(=O)c2c1

InChI Key: InChIKey=IBFGWMAGFFTUJG-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50215419   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Coagulation factor VII (Homo sapiens (Human))	BDBM50215419 (CHEMBL243537 | N-((1-amino-4-oxo-3,4-dihydrophthal...) Show SMILES Nc1cccc(c1)-c1c(Cl)nc(NC2CCC2)c(=O)n1CC(=O)NCc1ccc2c(N)n[nH]c(=O)c2c1 Show InChI InChI=1S/C25H25ClN8O3/c26-21-20(14-3-1-4-15(27)10-14)34(25(37)23(31-21)30-16-5-2-6-16)12-19(35)29-11-13-7-8-17-18(9-13)24(36)33-32-22(17)28/h1,3-4,7-10,16H,2,5-6,11-12,27H2,(H2,28,32)(H,29,35)(H,30,31)(H,33,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of factor 7a				Bioorg Med Chem Lett 17: 4568-74 (2007) Article DOI: 10.1016/j.bmcl.2007.05.090 BindingDB Entry DOI: 10.7270/Q2319VK8
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM50215419 (CHEMBL243537 | N-((1-amino-4-oxo-3,4-dihydrophthal...) Show SMILES Nc1cccc(c1)-c1c(Cl)nc(NC2CCC2)c(=O)n1CC(=O)NCc1ccc2c(N)n[nH]c(=O)c2c1 Show InChI InChI=1S/C25H25ClN8O3/c26-21-20(14-3-1-4-15(27)10-14)34(25(37)23(31-21)30-16-5-2-6-16)12-19(35)29-11-13-7-8-17-18(9-13)24(36)33-32-22(17)28/h1,3-4,7-10,16H,2,5-6,11-12,27H2,(H2,28,32)(H,29,35)(H,30,31)(H,33,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of factor 2a				Bioorg Med Chem Lett 17: 4568-74 (2007) Article DOI: 10.1016/j.bmcl.2007.05.090 BindingDB Entry DOI: 10.7270/Q2319VK8
					More data for this Ligand-Target Pair
Coagulation factor X (Homo sapiens (Human))	BDBM50215419 (CHEMBL243537 | N-((1-amino-4-oxo-3,4-dihydrophthal...) Show SMILES Nc1cccc(c1)-c1c(Cl)nc(NC2CCC2)c(=O)n1CC(=O)NCc1ccc2c(N)n[nH]c(=O)c2c1 Show InChI InChI=1S/C25H25ClN8O3/c26-21-20(14-3-1-4-15(27)10-14)34(25(37)23(31-21)30-16-5-2-6-16)12-19(35)29-11-13-7-8-17-18(9-13)24(36)33-32-22(17)28/h1,3-4,7-10,16H,2,5-6,11-12,27H2,(H2,28,32)(H,29,35)(H,30,31)(H,33,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of factor 10a				Bioorg Med Chem Lett 17: 4568-74 (2007) Article DOI: 10.1016/j.bmcl.2007.05.090 BindingDB Entry DOI: 10.7270/Q2319VK8
					More data for this Ligand-Target Pair