BDBM50215420 4-({2-[6-(3-aminophenyl)-5-chloro-3-(cyclobutylamino)-2-oxo-1,2-dihydropyrazin-1-yl]ethyl}sulfamoyl)benzene-1-carboximidamide::CHEMBL389527

SMILES: NC(=N)c1ccc(cc1)S(=O)(=O)NCCn1c(c(Cl)nc(NC2CCC2)c1=O)-c1cccc(N)c1

InChI Key: InChIKey=SDKQVJOMLLWQKD-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50215420   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Coagulation factor X (Homo sapiens (Human))	BDBM50215420 (4-({2-[6-(3-aminophenyl)-5-chloro-3-(cyclobutylami...) Show SMILES NC(=N)c1ccc(cc1)S(=O)(=O)NCCn1c(c(Cl)nc(NC2CCC2)c1=O)-c1cccc(N)c1 Show InChI InChI=1S/C23H26ClN7O3S/c24-20-19(15-3-1-4-16(25)13-15)31(23(32)22(30-20)29-17-5-2-6-17)12-11-28-35(33,34)18-9-7-14(8-10-18)21(26)27/h1,3-4,7-10,13,17,28H,2,5-6,11-12,25H2,(H3,26,27)(H,29,30)	PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of factor 10a				Bioorg Med Chem Lett 17: 4568-74 (2007) Article DOI: 10.1016/j.bmcl.2007.05.090 BindingDB Entry DOI: 10.7270/Q2319VK8
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM50215420 (4-({2-[6-(3-aminophenyl)-5-chloro-3-(cyclobutylami...) Show SMILES NC(=N)c1ccc(cc1)S(=O)(=O)NCCn1c(c(Cl)nc(NC2CCC2)c1=O)-c1cccc(N)c1 Show InChI InChI=1S/C23H26ClN7O3S/c24-20-19(15-3-1-4-16(25)13-15)31(23(32)22(30-20)29-17-5-2-6-17)12-11-28-35(33,34)18-9-7-14(8-10-18)21(26)27/h1,3-4,7-10,13,17,28H,2,5-6,11-12,25H2,(H3,26,27)(H,29,30)	PDB GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of factor 2a				Bioorg Med Chem Lett 17: 4568-74 (2007) Article DOI: 10.1016/j.bmcl.2007.05.090 BindingDB Entry DOI: 10.7270/Q2319VK8
					More data for this Ligand-Target Pair
Coagulation factor VII (Homo sapiens (Human))	BDBM50215420 (4-({2-[6-(3-aminophenyl)-5-chloro-3-(cyclobutylami...) Show SMILES NC(=N)c1ccc(cc1)S(=O)(=O)NCCn1c(c(Cl)nc(NC2CCC2)c1=O)-c1cccc(N)c1 Show InChI InChI=1S/C23H26ClN7O3S/c24-20-19(15-3-1-4-16(25)13-15)31(23(32)22(30-20)29-17-5-2-6-17)12-11-28-35(33,34)18-9-7-14(8-10-18)21(26)27/h1,3-4,7-10,13,17,28H,2,5-6,11-12,25H2,(H3,26,27)(H,29,30)	PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of factor 7a				Bioorg Med Chem Lett 17: 4568-74 (2007) Article DOI: 10.1016/j.bmcl.2007.05.090 BindingDB Entry DOI: 10.7270/Q2319VK8
					More data for this Ligand-Target Pair