BDBM50215423 2-(6-(3-aminophenyl)-5-chloro-3-(cyclobutylamino)-2-oxopyrazin-1(2H)-yl)-N-benzylacetamide::CHEMBL390662
SMILES: Nc1cccc(c1)-c1c(Cl)nc(NC2CCC2)c(=O)n1CC(=O)NCc1ccccc1
InChI Key: InChIKey=HFKPIILZWZGLCQ-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Prothrombin (Homo sapiens (Human)) | BDBM50215423 (2-(6-(3-aminophenyl)-5-chloro-3-(cyclobutylamino)-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.06E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Inhibition of factor 2a | Bioorg Med Chem Lett 17: 4568-74 (2007) Article DOI: 10.1016/j.bmcl.2007.05.090 BindingDB Entry DOI: 10.7270/Q2319VK8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor X (Homo sapiens (Human)) | BDBM50215423 (2-(6-(3-aminophenyl)-5-chloro-3-(cyclobutylamino)-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Inhibition of factor 10a | Bioorg Med Chem Lett 17: 4568-74 (2007) Article DOI: 10.1016/j.bmcl.2007.05.090 BindingDB Entry DOI: 10.7270/Q2319VK8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor VII (Homo sapiens (Human)) | BDBM50215423 (2-(6-(3-aminophenyl)-5-chloro-3-(cyclobutylamino)-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Inhibition of factor 7a | Bioorg Med Chem Lett 17: 4568-74 (2007) Article DOI: 10.1016/j.bmcl.2007.05.090 BindingDB Entry DOI: 10.7270/Q2319VK8 | |||||||||||
More data for this Ligand-Target Pair |