BDBM50216172 (Dichloro-phosphono-methyl)-phosphonic acid::CHEMBL12318::bisphosphonate clodronate::clodronic acid

SMILES: OP(O)(=O)C(Cl)(Cl)P(O)(O)=O

InChI Key: InChIKey=ACSIXWWBWUQEHA-UHFFFAOYSA-N

Data: 1 KI  4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50216172   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Type IV secretion-like conjugative transfer relaxase protein TraI (Escherichia coli (strain SMS-3-5 / SECEC))	BDBM50216172 ((Dichloro-phosphono-methyl)-phosphonic acid | CHEM...) Show SMILES OP(O)(=O)C(Cl)(Cl)P(O)(O)=O Show InChI InChI=1S/CH4Cl2O6P2/c2-1(3,10(4,5)6)11(7,8)9/h(H2,4,5,6)(H2,7,8,9)	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents	Article PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description Inhibition of Escherichia coli F plasmid TraI relaxase Y16F mutant assessed as oriT ssDNA cleavage by competitive inhibition assay				Proc Natl Acad Sci U S A 104: 12282-7 (2007) Article DOI: 10.1073/pnas.0702760104 BindingDB Entry DOI: 10.7270/Q2PK0JXD
					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50216172 ((Dichloro-phosphono-methyl)-phosphonic acid | CHEM...) Show SMILES OP(O)(=O)C(Cl)(Cl)P(O)(O)=O Show InChI InChI=1S/CH4Cl2O6P2/c2-1(3,10(4,5)6)11(7,8)9/h(H2,4,5,6)(H2,7,8,9)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Università di Bari Curated by ChEMBL					Assay Description Inhibition of human recombinant MMP3 after 1 hr				J Med Chem 50: 3434-41 (2007) Article DOI: 10.1021/jm061435l BindingDB Entry DOI: 10.7270/Q2G44Q0J
					More data for this Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12) (Homo sapiens (Human))	BDBM50216172 ((Dichloro-phosphono-methyl)-phosphonic acid | CHEM...) Show SMILES OP(O)(=O)C(Cl)(Cl)P(O)(O)=O Show InChI InChI=1S/CH4Cl2O6P2/c2-1(3,10(4,5)6)11(7,8)9/h(H2,4,5,6)(H2,7,8,9)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	1.21E+5	n/a	n/a	n/a	n/a	n/a	n/a
Università di Bari Curated by ChEMBL					Assay Description Inhibition of human recombinant MMP12 after 1 hr				J Med Chem 50: 3434-41 (2007) Article DOI: 10.1021/jm061435l BindingDB Entry DOI: 10.7270/Q2G44Q0J
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50216172 ((Dichloro-phosphono-methyl)-phosphonic acid | CHEM...) Show SMILES OP(O)(=O)C(Cl)(Cl)P(O)(O)=O Show InChI InChI=1S/CH4Cl2O6P2/c2-1(3,10(4,5)6)11(7,8)9/h(H2,4,5,6)(H2,7,8,9)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	3.20E+5	n/a	n/a	n/a	n/a	n/a	n/a
Università di Bari Curated by ChEMBL					Assay Description Inhibition of human recombinant MMP9 after 1 hr				J Med Chem 50: 3434-41 (2007) Article DOI: 10.1021/jm061435l BindingDB Entry DOI: 10.7270/Q2G44Q0J
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50216172 ((Dichloro-phosphono-methyl)-phosphonic acid | CHEM...) Show SMILES OP(O)(=O)C(Cl)(Cl)P(O)(O)=O Show InChI InChI=1S/CH4Cl2O6P2/c2-1(3,10(4,5)6)11(7,8)9/h(H2,4,5,6)(H2,7,8,9)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	1.45E+5	n/a	n/a	n/a	n/a	n/a	n/a
Università di Bari Curated by ChEMBL					Assay Description Inhibition of human recombinant MMP2 after 1 hr				J Med Chem 50: 3434-41 (2007) Article DOI: 10.1021/jm061435l BindingDB Entry DOI: 10.7270/Q2G44Q0J
					More data for this Ligand-Target Pair