BDBM50217556 CHEMBL125828

SMILES: O=C(N[C@@H]1N=C(c2ccccc2)c2cccc3CCN(c23)C1=O)c1cc2ccccc2cn1

InChI Key: InChIKey=MHRHYMTVTFSTHJ-VWLOTQADSA-N

Data: 7 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50217556   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphodiesterase 4 (Homo sapiens (Human))	BDBM50217556 (CHEMBL125828) Show SMILES O=C(N[C@@H]1N=C(c2ccccc2)c2cccc3CCN(c23)C1=O)c1cc2ccccc2cn1 |t:4| Show InChI InChI=1S/C27H20N4O2/c32-26(22-15-19-9-4-5-10-20(19)16-28-22)30-25-27(33)31-14-13-18-11-6-12-21(24(18)31)23(29-25)17-7-2-1-3-8-17/h1-12,15-16,25H,13-14H2,(H,30,32)/t25-/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	4.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institut de Recherche Jouveinal-Parke Davis Curated by ChEMBL					Assay Description Inhibition of phosphodiesterase 4 extracted from human U937 cells by using radioligands [3H]-cAMP or [3H]cGMP.				Bioorg Med Chem Lett 10: 35-8 (2000) BindingDB Entry DOI: 10.7270/Q25Q4Z9J
					More data for this Ligand-Target Pair
Phosphodiesterase 3 (Homo sapiens (Human))	BDBM50217556 (CHEMBL125828) Show SMILES O=C(N[C@@H]1N=C(c2ccccc2)c2cccc3CCN(c23)C1=O)c1cc2ccccc2cn1 |t:4| Show InChI InChI=1S/C27H20N4O2/c32-26(22-15-19-9-4-5-10-20(19)16-28-22)30-25-27(33)31-14-13-18-11-6-12-21(24(18)31)23(29-25)17-7-2-1-3-8-17/h1-12,15-16,25H,13-14H2,(H,30,32)/t25-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Institut de Recherche Jouveinal-Parke Davis Curated by ChEMBL					Assay Description Inhibition of Phosphodiesterase 3 extracted from dog aorta smooth muscle cells by using radioligands [3H]cAMP or [3H]-cGMP.				Bioorg Med Chem Lett 10: 35-8 (2000) BindingDB Entry DOI: 10.7270/Q25Q4Z9J
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C (Rattus norvegicus)	BDBM50217556 (CHEMBL125828) Show SMILES O=C(N[C@@H]1N=C(c2ccccc2)c2cccc3CCN(c23)C1=O)c1cc2ccccc2cn1 |t:4| Show InChI InChI=1S/C27H20N4O2/c32-26(22-15-19-9-4-5-10-20(19)16-28-22)30-25-27(33)31-14-13-18-11-6-12-21(24(18)31)23(29-25)17-7-2-1-3-8-17/h1-12,15-16,25H,13-14H2,(H,30,32)/t25-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institut de Recherche Jouveinal-Parke Davis Curated by ChEMBL					Assay Description Binding affinity against high affinity rolipram binding site (HARBS) was determined by displacing radioactive [3H]rolipram from brain membrane suspen...				Bioorg Med Chem Lett 10: 35-8 (2000) BindingDB Entry DOI: 10.7270/Q25Q4Z9J
					More data for this Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5 (Homo sapiens (Human))	BDBM50217556 (CHEMBL125828) Show SMILES O=C(N[C@@H]1N=C(c2ccccc2)c2cccc3CCN(c23)C1=O)c1cc2ccccc2cn1 |t:4| Show InChI InChI=1S/C27H20N4O2/c32-26(22-15-19-9-4-5-10-20(19)16-28-22)30-25-27(33)31-14-13-18-11-6-12-21(24(18)31)23(29-25)17-7-2-1-3-8-17/h1-12,15-16,25H,13-14H2,(H,30,32)/t25-/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of phosphodiesterase 1/5 isozyme (PDE1/5) mixture isolated from the guinea pig trachea.				J Med Chem 43: 4850-67 (2000) Article DOI: 10.1021/jm000315p BindingDB Entry DOI: 10.7270/Q25M68FS
					More data for this Ligand-Target Pair
Phosphodiesterase 3 (Homo sapiens (Human))	BDBM50217556 (CHEMBL125828) Show SMILES O=C(N[C@@H]1N=C(c2ccccc2)c2cccc3CCN(c23)C1=O)c1cc2ccccc2cn1 |t:4| Show InChI InChI=1S/C27H20N4O2/c32-26(22-15-19-9-4-5-10-20(19)16-28-22)30-25-27(33)31-14-13-18-11-6-12-21(24(18)31)23(29-25)17-7-2-1-3-8-17/h1-12,15-16,25H,13-14H2,(H,30,32)/t25-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of phosphodiesterase 3 (PDE3) isolated from the dog aorta				J Med Chem 43: 4850-67 (2000) Article DOI: 10.1021/jm000315p BindingDB Entry DOI: 10.7270/Q25M68FS
					More data for this Ligand-Target Pair
Phosphodiesterase 4 (Homo sapiens (Human))	BDBM50217556 (CHEMBL125828) Show SMILES O=C(N[C@@H]1N=C(c2ccccc2)c2cccc3CCN(c23)C1=O)c1cc2ccccc2cn1 |t:4| Show InChI InChI=1S/C27H20N4O2/c32-26(22-15-19-9-4-5-10-20(19)16-28-22)30-25-27(33)31-14-13-18-11-6-12-21(24(18)31)23(29-25)17-7-2-1-3-8-17/h1-12,15-16,25H,13-14H2,(H,30,32)/t25-/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of phosphodiesterase type 4 isozyme (PDE4) from the U937 human cell line.				J Med Chem 43: 4850-67 (2000) Article DOI: 10.1021/jm000315p BindingDB Entry DOI: 10.7270/Q25M68FS
					More data for this Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5 (Homo sapiens (Human))	BDBM50217556 (CHEMBL125828) Show SMILES O=C(N[C@@H]1N=C(c2ccccc2)c2cccc3CCN(c23)C1=O)c1cc2ccccc2cn1 |t:4| Show InChI InChI=1S/C27H20N4O2/c32-26(22-15-19-9-4-5-10-20(19)16-28-22)30-25-27(33)31-14-13-18-11-6-12-21(24(18)31)23(29-25)17-7-2-1-3-8-17/h1-12,15-16,25H,13-14H2,(H,30,32)/t25-/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Institut de Recherche Jouveinal-Parke Davis Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase 1/5 (PDE1/5) extracted from guinea pig trachea smooth muscle cells by using radioligands [3H]-cAMP or [...				Bioorg Med Chem Lett 10: 35-8 (2000) BindingDB Entry DOI: 10.7270/Q25Q4Z9J
					More data for this Ligand-Target Pair