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SMILES: COc1cc2nc(O)nc(c2cc1OC)C(F)(F)F

InChI Key: InChIKey=UOSOAWXVOPTSMQ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50226915   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B


(Homo sapiens (Human))		BDBM50226915
PNG
(CHEMBL284798)
Show SMILES COc1cc2nc(O)nc(c2cc1OC)C(F)(F)F
Show InChI InChI=1S/C11H9F3N2O3/c1-18-7-3-5-6(4-8(7)19-2)15-10(17)16-9(5)11(12,13)14/h3-4H,1-2H3,(H,15,16,17)
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PC cid
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Similars
PubMed
n/an/a 1.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against canine cardiac fraction III cyclic AMP phosphodiesterase (PDE III) at 8.75 mg/kg intravenous dose

J Med Chem 30: 1421-6 (1987)


BindingDB Entry DOI: 10.7270/Q21J9D0T
More data for this
Ligand-Target Pair