BDBM50227111 CHEMBL236587::N-(1-(3-ethoxy-4-methoxybenzyl)piperidin-4-yl)benzo[d]oxazol-2-amine

SMILES: CCOc1cc(CN2CCC(CC2)Nc2nc3ccccc3o2)ccc1OC

InChI Key: InChIKey=WUXDFTYUVPKGCE-UHFFFAOYSA-N

Data: 8 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50227111   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-hydroxytryptamine receptor 2B (Homo sapiens (Human))	BDBM50227111 (CHEMBL236587 | N-(1-(3-ethoxy-4-methoxybenzyl)pipe...) Show SMILES CCOc1cc(CN2CCC(CC2)Nc2nc3ccccc3o2)ccc1OC Show InChI InChI=1S/C22H27N3O3/c1-3-27-21-14-16(8-9-20(21)26-2)15-25-12-10-17(11-13-25)23-22-24-18-6-4-5-7-19(18)28-22/h4-9,14,17H,3,10-13,15H2,1-2H3,(H,23,24)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	41	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Binding affinity to human 5HT2B receptor				Bioorg Med Chem Lett 19: 6106-13 (2009) Article DOI: 10.1016/j.bmcl.2009.09.024 BindingDB Entry DOI: 10.7270/Q2PC32H9
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM50227111 (CHEMBL236587 | N-(1-(3-ethoxy-4-methoxybenzyl)pipe...) Show SMILES CCOc1cc(CN2CCC(CC2)Nc2nc3ccccc3o2)ccc1OC Show InChI InChI=1S/C22H27N3O3/c1-3-27-21-14-16(8-9-20(21)26-2)15-25-12-10-17(11-13-25)23-22-24-18-6-4-5-7-19(18)28-22/h4-9,14,17H,3,10-13,15H2,1-2H3,(H,23,24)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	121	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Displacement of SST14 from human recombinant SST5 receptor expressed in CHO cells by radioligand binding assay				Bioorg Med Chem Lett 19: 6106-13 (2009) Article DOI: 10.1016/j.bmcl.2009.09.024 BindingDB Entry DOI: 10.7270/Q2PC32H9
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM50227111 (CHEMBL236587 | N-(1-(3-ethoxy-4-methoxybenzyl)pipe...) Show SMILES CCOc1cc(CN2CCC(CC2)Nc2nc3ccccc3o2)ccc1OC Show InChI InChI=1S/C22H27N3O3/c1-3-27-21-14-16(8-9-20(21)26-2)15-25-12-10-17(11-13-25)23-22-24-18-6-4-5-7-19(18)28-22/h4-9,14,17H,3,10-13,15H2,1-2H3,(H,23,24)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	121	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					Assay Description Displacement of [125I]11-Tyr somatostatin-14 from human SST5R expressed in CHO cells				J Med Chem 50: 6291-4 (2007) Article DOI: 10.1021/jm701143p BindingDB Entry DOI: 10.7270/Q2WS8T0K
					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM50227111 (CHEMBL236587 | N-(1-(3-ethoxy-4-methoxybenzyl)pipe...) Show SMILES CCOc1cc(CN2CCC(CC2)Nc2nc3ccccc3o2)ccc1OC Show InChI InChI=1S/C22H27N3O3/c1-3-27-21-14-16(8-9-20(21)26-2)15-25-12-10-17(11-13-25)23-22-24-18-6-4-5-7-19(18)28-22/h4-9,14,17H,3,10-13,15H2,1-2H3,(H,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	624	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					Assay Description Binding affinity to histamine H1 receptor				J Med Chem 50: 6291-4 (2007) Article DOI: 10.1021/jm701143p BindingDB Entry DOI: 10.7270/Q2WS8T0K
					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM50227111 (CHEMBL236587 | N-(1-(3-ethoxy-4-methoxybenzyl)pipe...) Show SMILES CCOc1cc(CN2CCC(CC2)Nc2nc3ccccc3o2)ccc1OC Show InChI InChI=1S/C22H27N3O3/c1-3-27-21-14-16(8-9-20(21)26-2)15-25-12-10-17(11-13-25)23-22-24-18-6-4-5-7-19(18)28-22/h4-9,14,17H,3,10-13,15H2,1-2H3,(H,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	624	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Binding affinity to human histamine H1 receptor				Bioorg Med Chem Lett 19: 6106-13 (2009) Article DOI: 10.1016/j.bmcl.2009.09.024 BindingDB Entry DOI: 10.7270/Q2PC32H9
					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM50227111 (CHEMBL236587 | N-(1-(3-ethoxy-4-methoxybenzyl)pipe...) Show SMILES CCOc1cc(CN2CCC(CC2)Nc2nc3ccccc3o2)ccc1OC Show InChI InChI=1S/C22H27N3O3/c1-3-27-21-14-16(8-9-20(21)26-2)15-25-12-10-17(11-13-25)23-22-24-18-6-4-5-7-19(18)28-22/h4-9,14,17H,3,10-13,15H2,1-2H3,(H,23,24)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Displacement of SST14 from human recombinant SST2 receptor				Bioorg Med Chem Lett 19: 6106-13 (2009) Article DOI: 10.1016/j.bmcl.2009.09.024 BindingDB Entry DOI: 10.7270/Q2PC32H9
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM50227111 (CHEMBL236587 | N-(1-(3-ethoxy-4-methoxybenzyl)pipe...) Show SMILES CCOc1cc(CN2CCC(CC2)Nc2nc3ccccc3o2)ccc1OC Show InChI InChI=1S/C22H27N3O3/c1-3-27-21-14-16(8-9-20(21)26-2)15-25-12-10-17(11-13-25)23-22-24-18-6-4-5-7-19(18)28-22/h4-9,14,17H,3,10-13,15H2,1-2H3,(H,23,24)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Displacement of SST14 from human recombinant SST3 receptor				Bioorg Med Chem Lett 19: 6106-13 (2009) Article DOI: 10.1016/j.bmcl.2009.09.024 BindingDB Entry DOI: 10.7270/Q2PC32H9
					More data for this Ligand-Target Pair
Somatostatin receptor type 4 (Homo sapiens (Human))	BDBM50227111 (CHEMBL236587 | N-(1-(3-ethoxy-4-methoxybenzyl)pipe...) Show SMILES CCOc1cc(CN2CCC(CC2)Nc2nc3ccccc3o2)ccc1OC Show InChI InChI=1S/C22H27N3O3/c1-3-27-21-14-16(8-9-20(21)26-2)15-25-12-10-17(11-13-25)23-22-24-18-6-4-5-7-19(18)28-22/h4-9,14,17H,3,10-13,15H2,1-2H3,(H,23,24)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Displacement of SST14 from human recombinant SST4 receptor				Bioorg Med Chem Lett 19: 6106-13 (2009) Article DOI: 10.1016/j.bmcl.2009.09.024 BindingDB Entry DOI: 10.7270/Q2PC32H9
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM50227111 (CHEMBL236587 | N-(1-(3-ethoxy-4-methoxybenzyl)pipe...) Show SMILES CCOc1cc(CN2CCC(CC2)Nc2nc3ccccc3o2)ccc1OC Show InChI InChI=1S/C22H27N3O3/c1-3-27-21-14-16(8-9-20(21)26-2)15-25-12-10-17(11-13-25)23-22-24-18-6-4-5-7-19(18)28-22/h4-9,14,17H,3,10-13,15H2,1-2H3,(H,23,24)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	740	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					Assay Description Antagonist activity at human SST5R expressed in CHO cells assessed as reversal of somatostatin-14 induced cAMP response				J Med Chem 50: 6291-4 (2007) Article DOI: 10.1021/jm701143p BindingDB Entry DOI: 10.7270/Q2WS8T0K
					More data for this Ligand-Target Pair