BDBM50227712 CHEMBL254816::N-hydroxy-2-[4-(2-trifluoromethyl-biphenyl-4-yl)-3,6-dihydro-2H-pyridine-1-sulfonyl]-acetamide

SMILES: ONC(=O)CS(=O)(=O)N1CCC(=CC1)c1ccc(-c2ccccc2)c(c1)C(F)(F)F

InChI Key: InChIKey=URSVZCYOMZVHJE-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50227712   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Stromelysin-1 (Homo sapiens (Human))	BDBM50227712 (CHEMBL254816 | N-hydroxy-2-[4-(2-trifluoromethyl-b...) Show SMILES ONC(=O)CS(=O)(=O)N1CCC(=CC1)c1ccc(-c2ccccc2)c(c1)C(F)(F)F |c:11| Show InChI InChI=1S/C20H19F3N2O4S/c21-20(22,23)18-12-16(6-7-17(18)15-4-2-1-3-5-15)14-8-10-25(11-9-14)30(28,29)13-19(26)24-27/h1-8,12,27H,9-11,13H2,(H,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	960	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of MMP3				Bioorg Med Chem Lett 17: 6750-3 (2008) Article DOI: 10.1016/j.bmcl.2007.10.042 BindingDB Entry DOI: 10.7270/Q20K289K
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50227712 (CHEMBL254816 | N-hydroxy-2-[4-(2-trifluoromethyl-b...) Show SMILES ONC(=O)CS(=O)(=O)N1CCC(=CC1)c1ccc(-c2ccccc2)c(c1)C(F)(F)F |c:11| Show InChI InChI=1S/C20H19F3N2O4S/c21-20(22,23)18-12-16(6-7-17(18)15-4-2-1-3-5-15)14-8-10-25(11-9-14)30(28,29)13-19(26)24-27/h1-8,12,27H,9-11,13H2,(H,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.08E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of MMP2				Bioorg Med Chem Lett 17: 6750-3 (2008) Article DOI: 10.1016/j.bmcl.2007.10.042 BindingDB Entry DOI: 10.7270/Q20K289K
					More data for this Ligand-Target Pair