BDBM50231789 CHEMBL4091379

SMILES: COc1ccc(Cn2cc(ccc2=O)-c2cc(nc(n2)S(C)(=O)=O)C(F)(F)F)cc1OC

InChI Key: InChIKey=RGZKCDYNLOHIOC-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50231789   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (Homo sapiens (Human))	BDBM50231789 (CHEMBL4091379) Show SMILES COc1ccc(Cn2cc(ccc2=O)-c2cc(nc(n2)S(C)(=O)=O)C(F)(F)F)cc1OC Show InChI InChI=1S/C20H18F3N3O5S/c1-30-15-6-4-12(8-16(15)31-2)10-26-11-13(5-7-18(26)27)14-9-17(20(21,22)23)25-19(24-14)32(3,28)29/h4-9,11H,10H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	n/a	n/a	25	n/a	n/a	n/a	n/a
Peking University Curated by ChEMBL					Assay Description Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ...				ACS Med Chem Lett 8: 407-412 (2017) BindingDB Entry DOI: 10.7270/Q29Z9745
					More data for this Ligand-Target Pair