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SMILES: CC(C)(C)c1ccc2C(NC(=O)Nc3cccc4[nH]ncc34)C(F)(F)Cc2c1

InChI Key: InChIKey=BGZQKFANVOPJDS-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50232124   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM50232124
PNG
(1-(5-tert-butyl-2,2-difluoro-2,3-dihydro-1H-inden-...)
Show SMILES CC(C)(C)c1ccc2C(NC(=O)Nc3cccc4[nH]ncc34)C(F)(F)Cc2c1 |w:8.8|
Show InChI InChI=1S/C21H22F2N4O/c1-20(2,3)13-7-8-14-12(9-13)10-21(22,23)18(14)26-19(28)25-16-5-4-6-17-15(16)11-24-27-17/h4-9,11,18H,10H2,1-3H3,(H,24,27)(H2,25,26,28)
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n/an/a 216n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux

J Med Chem 51: 392-5 (2008)


Article DOI: 10.1021/jm701007g
BindingDB Entry DOI: 10.7270/Q218367F
More data for this
Ligand-Target Pair