Found 6 hits for monomerid = 50232546 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Prostaglandin E2 receptor
(Homo sapiens (Human)) | BDBM50232546
(CHEMBL4103046)Show SMILES OC(=O)c1ccc(CNC(=O)c2cc(F)cnc2Oc2ccc(F)cc2)cc1 Show InChI InChI=1S/C20H14F2N2O4/c21-14-5-7-16(8-6-14)28-19-17(9-15(22)11-24-19)18(25)23-10-12-1-3-13(4-2-12)20(26)27/h1-9,11H,10H2,(H,23,25)(H,26,27) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 73 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AskAt Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE from human EP4 receptor expressed in HEK293 cell membranes |
Bioorg Med Chem Lett 27: 1186-1192 (2017)
BindingDB Entry DOI: 10.7270/Q2Q242F0 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor
(Homo sapiens (Human)) | BDBM50232546
(CHEMBL4103046)Show SMILES OC(=O)c1ccc(CNC(=O)c2cc(F)cnc2Oc2ccc(F)cc2)cc1 Show InChI InChI=1S/C20H14F2N2O4/c21-14-5-7-16(8-6-14)28-19-17(9-15(22)11-24-19)18(25)23-10-12-1-3-13(4-2-12)20(26)27/h1-9,11H,10H2,(H,23,25)(H,26,27) | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AskAt Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP1 receptor |
Bioorg Med Chem Lett 27: 1186-1192 (2017)
BindingDB Entry DOI: 10.7270/Q2Q242F0 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor
(Homo sapiens (Human)) | BDBM50232546
(CHEMBL4103046)Show SMILES OC(=O)c1ccc(CNC(=O)c2cc(F)cnc2Oc2ccc(F)cc2)cc1 Show InChI InChI=1S/C20H14F2N2O4/c21-14-5-7-16(8-6-14)28-19-17(9-15(22)11-24-19)18(25)23-10-12-1-3-13(4-2-12)20(26)27/h1-9,11H,10H2,(H,23,25)(H,26,27) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AskAt Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP3 receptor |
Bioorg Med Chem Lett 27: 1186-1192 (2017)
BindingDB Entry DOI: 10.7270/Q2Q242F0 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM50232546
(CHEMBL4103046)Show SMILES OC(=O)c1ccc(CNC(=O)c2cc(F)cnc2Oc2ccc(F)cc2)cc1 Show InChI InChI=1S/C20H14F2N2O4/c21-14-5-7-16(8-6-14)28-19-17(9-15(22)11-24-19)18(25)23-10-12-1-3-13(4-2-12)20(26)27/h1-9,11H,10H2,(H,23,25)(H,26,27) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 575 | n/a | n/a | n/a | n/a | n/a | n/a |
AskAt Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP level by HTS assay |
Bioorg Med Chem Lett 27: 1186-1192 (2017)
BindingDB Entry DOI: 10.7270/Q2Q242F0 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor
(Homo sapiens (Human)) | BDBM50232546
(CHEMBL4103046)Show SMILES OC(=O)c1ccc(CNC(=O)c2cc(F)cnc2Oc2ccc(F)cc2)cc1 Show InChI InChI=1S/C20H14F2N2O4/c21-14-5-7-16(8-6-14)28-19-17(9-15(22)11-24-19)18(25)23-10-12-1-3-13(4-2-12)20(26)27/h1-9,11H,10H2,(H,23,25)(H,26,27) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 104 | n/a | n/a | n/a | n/a | n/a | n/a |
AskAt Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE from human EP4 receptor expressed in HEK293 cell membranes |
Bioorg Med Chem Lett 27: 1186-1192 (2017)
BindingDB Entry DOI: 10.7270/Q2Q242F0 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor
(Homo sapiens (Human)) | BDBM50232546
(CHEMBL4103046)Show SMILES OC(=O)c1ccc(CNC(=O)c2cc(F)cnc2Oc2ccc(F)cc2)cc1 Show InChI InChI=1S/C20H14F2N2O4/c21-14-5-7-16(8-6-14)28-19-17(9-15(22)11-24-19)18(25)23-10-12-1-3-13(4-2-12)20(26)27/h1-9,11H,10H2,(H,23,25)(H,26,27) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AskAt Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP2 receptor |
Bioorg Med Chem Lett 27: 1186-1192 (2017)
BindingDB Entry DOI: 10.7270/Q2Q242F0 |
More data for this
Ligand-Target Pair | |
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