BDBM50232549 CHEMBL4092846

SMILES: OC(=O)c1ccc(CNC(=O)c2cc(F)ccc2Oc2ccc(F)cc2)cc1

InChI Key: InChIKey=MKIRDUSAXONEOR-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50232549   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prostaglandin E2 receptor (Homo sapiens (Human))	BDBM50232549 (CHEMBL4092846) Show SMILES OC(=O)c1ccc(CNC(=O)c2cc(F)ccc2Oc2ccc(F)cc2)cc1 Show InChI InChI=1S/C21H15F2NO4/c22-15-5-8-17(9-6-15)28-19-10-7-16(23)11-18(19)20(25)24-12-13-1-3-14(4-2-13)21(26)27/h1-11H,12H2,(H,24,25)(H,26,27)	PDB Reactome pathway KEGG DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	124	n/a	n/a	n/a	n/a	n/a	n/a
AskAt Inc. Curated by ChEMBL					Assay Description Displacement of [3H]PGE from human EP4 receptor expressed in HEK293 cell membranes				Bioorg Med Chem Lett 27: 1186-1192 (2017) BindingDB Entry DOI: 10.7270/Q2Q242F0
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor (Homo sapiens (Human))	BDBM50232549 (CHEMBL4092846) Show SMILES OC(=O)c1ccc(CNC(=O)c2cc(F)ccc2Oc2ccc(F)cc2)cc1 Show InChI InChI=1S/C21H15F2NO4/c22-15-5-8-17(9-6-15)28-19-10-7-16(23)11-18(19)20(25)24-12-13-1-3-14(4-2-13)21(26)27/h1-11H,12H2,(H,24,25)(H,26,27)	KEGG DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
AskAt Inc. Curated by ChEMBL					Assay Description Antagonist activity at human EP1 receptor				Bioorg Med Chem Lett 27: 1186-1192 (2017) BindingDB Entry DOI: 10.7270/Q2Q242F0
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor (Homo sapiens (Human))	BDBM50232549 (CHEMBL4092846) Show SMILES OC(=O)c1ccc(CNC(=O)c2cc(F)ccc2Oc2ccc(F)cc2)cc1 Show InChI InChI=1S/C21H15F2NO4/c22-15-5-8-17(9-6-15)28-19-10-7-16(23)11-18(19)20(25)24-12-13-1-3-14(4-2-13)21(26)27/h1-11H,12H2,(H,24,25)(H,26,27)	PDB Reactome pathway KEGG DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	236	n/a	n/a	n/a	n/a	n/a	n/a
AskAt Inc. Curated by ChEMBL					Assay Description Antagonist activity at human EP2 receptor				Bioorg Med Chem Lett 27: 1186-1192 (2017) BindingDB Entry DOI: 10.7270/Q2Q242F0
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50232549 (CHEMBL4092846) Show SMILES OC(=O)c1ccc(CNC(=O)c2cc(F)ccc2Oc2ccc(F)cc2)cc1 Show InChI InChI=1S/C21H15F2NO4/c22-15-5-8-17(9-6-15)28-19-10-7-16(23)11-18(19)20(25)24-12-13-1-3-14(4-2-13)21(26)27/h1-11H,12H2,(H,24,25)(H,26,27)	PDB Reactome pathway KEGG DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	317	n/a	n/a	n/a	n/a	n/a	n/a
AskAt Inc. Curated by ChEMBL					Assay Description Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP level by HTS assay				Bioorg Med Chem Lett 27: 1186-1192 (2017) BindingDB Entry DOI: 10.7270/Q2Q242F0
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor (Homo sapiens (Human))	BDBM50232549 (CHEMBL4092846) Show SMILES OC(=O)c1ccc(CNC(=O)c2cc(F)ccc2Oc2ccc(F)cc2)cc1 Show InChI InChI=1S/C21H15F2NO4/c22-15-5-8-17(9-6-15)28-19-10-7-16(23)11-18(19)20(25)24-12-13-1-3-14(4-2-13)21(26)27/h1-11H,12H2,(H,24,25)(H,26,27)	PDB KEGG DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
AskAt Inc. Curated by ChEMBL					Assay Description Antagonist activity at human EP3 receptor				Bioorg Med Chem Lett 27: 1186-1192 (2017) BindingDB Entry DOI: 10.7270/Q2Q242F0
					More data for this Ligand-Target Pair