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BDBM50232557 CHEMBL4074660

SMILES: C[C@H](NC(=O)c1cc(Cl)cnc1Oc1ccc(F)c(F)c1)c1ccc(cc1)C(O)=O

InChI Key: InChIKey=NWAARQJHDWAZKA-NSHDSACASA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50232557   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM50232557
PNG
(CHEMBL4074660)
Show SMILES C[C@H](NC(=O)c1cc(Cl)cnc1Oc1ccc(F)c(F)c1)c1ccc(cc1)C(O)=O |r|
Show InChI InChI=1S/C21H15ClF2N2O4/c1-11(12-2-4-13(5-3-12)21(28)29)26-19(27)16-8-14(22)10-25-20(16)30-15-6-7-17(23)18(24)9-15/h2-11H,1H3,(H,26,27)(H,28,29)/t11-/m0/s1
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n/an/a<50n/an/an/an/an/an/a



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Curated by ChEMBL


Assay Description
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP level by HTS assay

Bioorg Med Chem Lett 27: 1186-1192 (2017)


BindingDB Entry DOI: 10.7270/Q2Q242F0
More data for this
Ligand-Target Pair