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SMILES: Fc1ccc(CC(=O)NC(=O)Nc2ccc(Oc3ncnn4ccc(-c5ccccc5)c34)c(F)c2)cc1

InChI Key: InChIKey=PWLNNRDAQPANDX-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50235564   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50235564
PNG
(1-(3-fluoro-4-(5-phenylpyrrolo[1,2-f][1,2,4]triazi...)
Show SMILES Fc1ccc(CC(=O)NC(=O)Nc2ccc(Oc3ncnn4ccc(-c5ccccc5)c34)c(F)c2)cc1
Show InChI InChI=1S/C27H19F2N5O3/c28-19-8-6-17(7-9-19)14-24(35)33-27(36)32-20-10-11-23(22(29)15-20)37-26-25-21(18-4-2-1-3-5-18)12-13-34(25)31-16-30-26/h1-13,15-16H,14H2,(H2,32,33,35,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 260n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50235564
PNG
(1-(3-fluoro-4-(5-phenylpyrrolo[1,2-f][1,2,4]triazi...)
Show SMILES Fc1ccc(CC(=O)NC(=O)Nc2ccc(Oc3ncnn4ccc(-c5ccccc5)c34)c(F)c2)cc1
Show InChI InChI=1S/C27H19F2N5O3/c28-19-8-6-17(7-9-19)14-24(35)33-27(36)32-20-10-11-23(22(29)15-20)37-26-25-21(18-4-2-1-3-5-18)12-13-34(25)31-16-30-26/h1-13,15-16H,14H2,(H2,32,33,35,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 260n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met expressed in insect cell-baculovirus expression system


Bioorg Med Chem Lett 18: 1945-51 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.121
BindingDB Entry DOI: 10.7270/Q2125SFV
More data for this
Ligand-Target Pair