BDBM50236144 CHEMBL4089935

SMILES: CCCCNc1nc(N)nc(C)c1CCc1ccccc1

InChI Key: InChIKey=RWMBDVJGYSHEFZ-UHFFFAOYSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50236144   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Toll-like receptor 7 (Homo sapiens (Human))	BDBM50236144 (CHEMBL4089935) Show SMILES CCCCNc1nc(N)nc(C)c1CCc1ccccc1 Show InChI InChI=1S/C17H24N4/c1-3-4-12-19-16-15(13(2)20-17(18)21-16)11-10-14-8-6-5-7-9-14/h5-9H,3-4,10-12H2,1-2H3,(H3,18,19,20,21)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.82E+3	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Agonist activity at human TLR7 expressed in HEK293 cells co-expressing secreted alkaline phosphatase assessed as induction of NF-kappaB/AP-1 promoter...				J Med Chem 60: 2084-2098 (2017) Article DOI: 10.1021/acs.jmedchem.6b01860 BindingDB Entry DOI: 10.7270/Q27083QG
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50236144 (CHEMBL4089935) Show SMILES CCCCNc1nc(N)nc(C)c1CCc1ccccc1 Show InChI InChI=1S/C17H24N4/c1-3-4-12-19-16-15(13(2)20-17(18)21-16)11-10-14-8-6-5-7-9-14/h5-9H,3-4,10-12H2,1-2H3,(H3,18,19,20,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.19E+3	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Agonist activity at human TLR8 expressed in HEK293 cells co-expressing secreted alkaline phosphatase assessed as induction of NF-kappaB/AP-1 promoter...				J Med Chem 60: 2084-2098 (2017) Article DOI: 10.1021/acs.jmedchem.6b01860 BindingDB Entry DOI: 10.7270/Q27083QG
					More data for this Ligand-Target Pair