BDBM50239937 CHEMBL4083851::US10287286, Example 3
SMILES: N#Cc1ccc(cc1)-c1cccc2ncnn12
InChI Key: InChIKey=DEYMFBHALUHGST-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Egl nine homolog 2 (Homo sapiens (Human)) | BDBM50239937![]() (CHEMBL4083851 | US10287286, Example 3) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda California Inc. Curated by ChEMBL | Assay Description Inhibition of full length HIF-PHD1 (unknown origin) expressed in baculovirus infected sf9 cells using DLDLEMLAPYIPMDDDFQL/2-Oxoglutarate as substrate... | J Med Chem 60: 5663-5672 (2017) Article DOI: 10.1021/acs.jmedchem.7b00352 BindingDB Entry DOI: 10.7270/Q2GQ70XZ | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Egl nine homolog 2 (Homo sapiens (Human)) | BDBM50239937![]() (CHEMBL4083851 | US10287286, Example 3) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid PDB UniChem Similars | PDB US Patent | n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Universita degli Studi di Firenze | Assay Description The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ... | Bioorg Med Chem 16: 7424-8 (2008) BindingDB Entry DOI: 10.7270/Q2QJ7KMD | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) |