BDBM50239948 CHEMBL4071326::US9850225, Example 1166
SMILES: Cc1c(COc2cc(OCc3cccc(c3)C#N)c(CN3C[C@H](O)C[C@@H]3C(O)=O)cc2Cl)cccc1-c1ccc2OCCOc2c1
InChI Key: InChIKey=QBXVXKRWOVBUDB-GRKNLSHJSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Programmed cell death 1 ligand 1 (Homo sapiens (Human)) | BDBM50239948 (CHEMBL4071326 | US9850225, Example 1166) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and... | US Patent US9850225 (2017) BindingDB Entry DOI: 10.7270/Q2N018TZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Programmed cell death 1 ligand 1 (Homo sapiens (Human)) | BDBM50239948 (CHEMBL4071326 | US9850225, Example 1166) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Curated by ChEMBL | Assay Description Binding affinity to His-tagged PD-L1 (unknown origin) assessed as reduction in PD-L1/PD1-Ig interaction preincubated with PD-L1 for 15 mins followed ... | J Med Chem 60: 5857-5867 (2017) Article DOI: 10.1021/acs.jmedchem.7b00293 BindingDB Entry DOI: 10.7270/Q2765HHP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Programmed cell death 1 ligand 1 (Homo sapiens (Human)) | BDBM50239948 (CHEMBL4071326 | US9850225, Example 1166) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | n/a | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PD-1/PD-L1 (Homo sapiens-Homo sapiens (Human)) | BDBM50239948 (CHEMBL4071326 | US9850225, Example 1166) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PD-1/PD-L1 (Homo sapiens-Homo sapiens (Human)) | BDBM50239948 (CHEMBL4071326 | US9850225, Example 1166) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Southern Medical University Curated by ChEMBL | Assay Description Inhibition of human PD1/PDL1 protein-protein interaction by HTRF assay | J Med Chem 63: 8338-8358 (2020) | |||||||||||
More data for this Ligand-Target Pair |