BindingDB PrimarySearch

BDBM50240436 2-Hydroxy-6-pentadecyl-benzoic acid::2-hydroxy-6-pentadecylbenzoic acid::6-(pentadecenyl)salicylic acid::anacardic acid

SMILES: CCCCCCCCCCCCCCCc1cccc(O)c1C(O)=O

InChI Key: InChIKey=ADFWQBGTDJIESE-UHFFFAOYSA-N

Data: 1 KI 15 IC50 1 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50240436
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Histone acetyltransferase KAT8 (Homo sapiens (Human))	BDBM50240436 (2-Hydroxy-6-pentadecyl-benzoic acid \| 2-hydroxy-6-...) Show SMILES CCCCCCCCCCCCCCCc1cccc(O)c1C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	6.40E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Inhibition of recombinant N-terminal His6-tagged KAT8 (unknown origin) expressed in Escherichia Coli BL21 DE3 cells assessed as reduction of Co A lev...				Eur J Med Chem 105: 289-96 (2015) Article DOI: 10.1016/j.ejmech.2015.10.016 BindingDB Entry DOI: 10.7270/Q2TT4TXW
University of Groningen Curated by ChEMBL					More data for this Ligand-Target Pair
Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50240436 (2-Hydroxy-6-pentadecyl-benzoic acid \| 2-hydroxy-6-...) Show SMILES CCCCCCCCCCCCCCCc1cccc(O)c1C(O)=O Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of recombinant human full-length His6-tagged p300 expressed in baculovirus infected Sf21 insect cells using [3H]acetylCoA as substrate pre...				J Med Chem 63: 1337-1360 (2020) Article DOI: 10.1021/acs.jmedchem.9b01721
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Histone acetyltransferase KAT2B (Homo sapiens (Human))	BDBM50240436 (2-Hydroxy-6-pentadecyl-benzoic acid \| 2-hydroxy-6-...) Show SMILES CCCCCCCCCCCCCCCc1cccc(O)c1C(O)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	3.39E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Freiburg Curated by ChEMBL					Assay Description Inhibition of recombinant human PCAF catalytic domain (492 to 658 residues) using histone H3 peptide substrate after 1 hr by liquid scintillation cou...				J Med Chem 59: 1249-70 (2016) BindingDB Entry DOI: 10.7270/Q2DV1MRN
University of Freiburg Curated by ChEMBL					More data for this Ligand-Target Pair
Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50240436 (2-Hydroxy-6-pentadecyl-benzoic acid \| 2-hydroxy-6-...) Show SMILES CCCCCCCCCCCCCCCc1cccc(O)c1C(O)=O Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	4.15E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Freiburg Curated by ChEMBL					Assay Description Inhibition of recombinant p300 catalytic domain (unknown origin) using N-terminal histone H3 substrate by radiometric filter binding assay in presenc...				J Med Chem 59: 1249-70 (2016) BindingDB Entry DOI: 10.7270/Q2DV1MRN
University of Freiburg Curated by ChEMBL					More data for this Ligand-Target Pair
Seed linoleate 13S-lipoxygenase-1 (Glycine max (soybean))	BDBM50240436 (2-Hydroxy-6-pentadecyl-benzoic acid \| 2-hydroxy-6-...) Show SMILES CCCCCCCCCCCCCCCc1cccc(O)c1C(O)=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	8.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of soybean lipoxygenase-1				J Nat Prod 57: 1755-1757 (1994) Article DOI: 10.1021/np50114a025 BindingDB Entry DOI: 10.7270/Q23B6042
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
SUMO-activating enzyme subunit 1 (Homo sapiens (Human))	BDBM50240436 (2-Hydroxy-6-pentadecyl-benzoic acid \| 2-hydroxy-6-...) Show SMILES CCCCCCCCCCCCCCCc1cccc(O)c1C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Toronto Mississauga Curated by ChEMBL					Assay Description Inhibition of recombinant SAE1(unknown origin)-mediated SUMOylation of RanGAP1-C2				J Med Chem 56: 2165-77 (2013) Article DOI: 10.1021/jm301420b BindingDB Entry DOI: 10.7270/Q29P32ZT
University of Toronto Mississauga Curated by ChEMBL					More data for this Ligand-Target Pair
Seed linoleate 13S-lipoxygenase-1 (Glycine max (soybean))	BDBM50240436 (2-Hydroxy-6-pentadecyl-benzoic acid \| 2-hydroxy-6-...) Show SMILES CCCCCCCCCCCCCCCc1cccc(O)c1C(O)=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.19E+4	n/a	n/a	n/a	n/a	n/a	n/a
Groningen Research Institute of Pharmacy Curated by ChEMBL					Assay Description Inhibition of soyabean lipoxygenase-1 assessed as formation of 13-HPOD from linolenic acid preincubated for 10 mins measured by real-time spectrophot...				Bioorg Med Chem 20: 5027-32 (2012) Article DOI: 10.1016/j.bmc.2012.06.019 BindingDB Entry DOI: 10.7270/Q20R9QJG
Groningen Research Institute of Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair
Probable linoleate 9S-lipoxygenase 5 (Solanum tuberosum)	BDBM50240436 (2-Hydroxy-6-pentadecyl-benzoic acid \| 2-hydroxy-6-...) Show SMILES CCCCCCCCCCCCCCCc1cccc(O)c1C(O)=O Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Groningen Research Institute of Pharmacy Curated by ChEMBL					Assay Description Inhibition of potato 5-lipoxygenase assessed as residual activity preincubated for 10 mins measured by real-time spectrophotometric analysis				Bioorg Med Chem 20: 5027-32 (2012) Article DOI: 10.1016/j.bmc.2012.06.019 BindingDB Entry DOI: 10.7270/Q20R9QJG
Groningen Research Institute of Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair
Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50240436 (2-Hydroxy-6-pentadecyl-benzoic acid \| 2-hydroxy-6-...) Show SMILES CCCCCCCCCCCCCCCc1cccc(O)c1C(O)=O Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of recombinant His6-tagged human P300 expressed in Baculovirus-infected Sf21 cells using histone peptide as substrate after 10 mins in pre...				Bioorg Med Chem 26: 5397-5407 (2018) Article DOI: 10.1016/j.bmc.2018.07.048 BindingDB Entry DOI: 10.7270/Q2ZW1PM0
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Histone acetyltransferase KAT2B (Homo sapiens (Human))	BDBM50240436 (2-Hydroxy-6-pentadecyl-benzoic acid \| 2-hydroxy-6-...) Show SMILES CCCCCCCCCCCCCCCc1cccc(O)c1C(O)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of recombinant FLAG epitope-tagged human PCAF expressed in Baculovirus-infected Sf21 cells using histone peptide as substrate after 10 min...				Bioorg Med Chem 26: 5397-5407 (2018) Article DOI: 10.1016/j.bmc.2018.07.048 BindingDB Entry DOI: 10.7270/Q2ZW1PM0
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Histone acetyltransferase KAT5 (Homo sapiens (Human))	BDBM50240436 (2-Hydroxy-6-pentadecyl-benzoic acid \| 2-hydroxy-6-...) Show SMILES CCCCCCCCCCCCCCCc1cccc(O)c1C(O)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of Tip60 (unknown origin)				Bioorg Med Chem 26: 5397-5407 (2018) Article DOI: 10.1016/j.bmc.2018.07.048 BindingDB Entry DOI: 10.7270/Q2ZW1PM0
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Histone acetyltransferase KAT8 (Homo sapiens (Human))	BDBM50240436 (2-Hydroxy-6-pentadecyl-benzoic acid \| 2-hydroxy-6-...) Show SMILES CCCCCCCCCCCCCCCc1cccc(O)c1C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of MOF (unknown origin)				Bioorg Med Chem 26: 5397-5407 (2018) Article DOI: 10.1016/j.bmc.2018.07.048 BindingDB Entry DOI: 10.7270/Q2ZW1PM0
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Histone acetyltransferase KAT8 (Homo sapiens (Human))	BDBM50240436 (2-Hydroxy-6-pentadecyl-benzoic acid \| 2-hydroxy-6-...) Show SMILES CCCCCCCCCCCCCCCc1cccc(O)c1C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.14E+11	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Inhibition of recombinant N-terminal His6-tagged KAT8 (unknown origin) expressed in Escherichia Coli BL21 DE3 cells assessed as reduction of Co A lev...				Eur J Med Chem 105: 289-96 (2015) Article DOI: 10.1016/j.ejmech.2015.10.016 BindingDB Entry DOI: 10.7270/Q2TT4TXW
University of Groningen Curated by ChEMBL					More data for this Ligand-Target Pair
Replicase polyprotein 1ab (2019-nCoV)	BDBM50240436 (2-Hydroxy-6-pentadecyl-benzoic acid \| 2-hydroxy-6-...) Show SMILES CCCCCCCCCCCCCCCc1cccc(O)c1C(O)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
National Institutes of Health					Assay Description The 3CLpro enzyme assay was developed in 384-well black, medium binding microplates (Greiner Bio-One, Monroe, NC, USA) with a total volume of 20 _...				bioRxiv (2020) Article DOI: 10.1101/2020.07.17.207019 BindingDB Entry DOI: 10.7270/Q20G3NJM
National Institutes of Health					More data for this Ligand-Target Pair
Replicase polyprotein 1ab (2019-nCoV)	BDBM50240436 (2-Hydroxy-6-pentadecyl-benzoic acid \| 2-hydroxy-6-...) Show SMILES CCCCCCCCCCCCCCCc1cccc(O)c1C(O)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	3.98E+3	n/a	n/a	n/a	n/a
National Institutes of Health					Assay Description SARS-CoV-2 CPE assay was conducted at Southern Research Institute (Birmingham, AL) as described in previous reports30, 31. In brief, high ACE2 expres...				bioRxiv (2020) Article DOI: 10.1101/2020.07.17.207019 BindingDB Entry DOI: 10.7270/Q20G3NJM
National Institutes of Health					More data for this Ligand-Target Pair
Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50240436 (2-Hydroxy-6-pentadecyl-benzoic acid \| 2-hydroxy-6-...) Show SMILES CCCCCCCCCCCCCCCc1cccc(O)c1C(O)=O Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	8.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Freiburg Curated by ChEMBL					Assay Description Inhibition of full length recombinant human His6-tagged p300 expressed in baculovirus infected Sf21 cells using N-terminal H3 peptide substrate after...				J Med Chem 59: 1249-70 (2016) BindingDB Entry DOI: 10.7270/Q2DV1MRN
University of Freiburg Curated by ChEMBL					More data for this Ligand-Target Pair
Histone acetyltransferase KAT2B (Homo sapiens (Human))	BDBM50240436 (2-Hydroxy-6-pentadecyl-benzoic acid \| 2-hydroxy-6-...) Show SMILES CCCCCCCCCCCCCCCc1cccc(O)c1C(O)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Freiburg Curated by ChEMBL					Assay Description Inhibition of full length recombinant human FLAG-tagged PCAF expressed in baculovirus infected Sf21 cells using N-terminal H3 peptide substrate after...				J Med Chem 59: 1249-70 (2016) BindingDB Entry DOI: 10.7270/Q2DV1MRN
University of Freiburg Curated by ChEMBL					More data for this Ligand-Target Pair