BDBM50240580 CHEMBL4070782

SMILES: COc1cc(OC)c(F)c(COc2cnc(Nc3ccccc3NC(=O)C=C)nc2)c1F

InChI Key: InChIKey=XAHULVPUYSIBDC-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50240580   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM50240580 (CHEMBL4070782) Show SMILES COc1cc(OC)c(F)c(COc2cnc(Nc3ccccc3NC(=O)C=C)nc2)c1F Show InChI InChI=1S/C22H20F2N4O4/c1-4-19(29)27-15-7-5-6-8-16(15)28-22-25-10-13(11-26-22)32-12-14-20(23)17(30-2)9-18(31-3)21(14)24/h4-11H,1,12H2,2-3H3,(H,27,29)(H,25,26,28)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec (Shanghai) Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal His-tagged FGFR4 cytoplasmic domain (781 to 133 residues) expressed in baculovirus expression system using...				Bioorg Med Chem Lett 27: 2420-2423 (2017) Article DOI: 10.1016/j.bmcl.2017.04.014 BindingDB Entry DOI: 10.7270/Q2M90BT6
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM50240580 (CHEMBL4070782) Show SMILES COc1cc(OC)c(F)c(COc2cnc(Nc3ccccc3NC(=O)C=C)nc2)c1F Show InChI InChI=1S/C22H20F2N4O4/c1-4-19(29)27-15-7-5-6-8-16(15)28-22-25-10-13(11-26-22)32-12-14-20(23)17(30-2)9-18(31-3)21(14)24/h4-11H,1,12H2,2-3H3,(H,27,29)(H,25,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec (Shanghai) Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant human His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus expression system using tyr 04 as ...				Bioorg Med Chem Lett 27: 2420-2423 (2017) Article DOI: 10.1016/j.bmcl.2017.04.014 BindingDB Entry DOI: 10.7270/Q2M90BT6
					More data for this Ligand-Target Pair