BDBM50241024 CHEMBL4076950

SMILES: Fc1cc(F)c(Nc2ccc3c(OCc4ccc(cc4C3=O)C(=O)NCCN3CCOCC3)c2)cc1NC(=O)c1cccs1

InChI Key: InChIKey=RVQWHBDNQHKJEP-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50241024   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50241024 (CHEMBL4076950) Show SMILES Fc1cc(F)c(Nc2ccc3c(OCc4ccc(cc4C3=O)C(=O)NCCN3CCOCC3)c2)cc1NC(=O)c1cccs1 Show InChI InChI=1S/C32H28F2N4O5S/c33-24-16-25(34)27(37-32(41)29-2-1-13-44-29)17-26(24)36-21-5-6-22-28(15-21)43-18-20-4-3-19(14-23(20)30(22)39)31(40)35-7-8-38-9-11-42-12-10-38/h1-6,13-17,36H,7-12,18H2,(H,35,40)(H,37,41)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	152	n/a	n/a	n/a	n/a	n/a	n/a
Eberhard-Karls-Universitaet Tuebingen Curated by ChEMBL					Assay Description Inhibition of P38 alpha MAPK in human whole blood assessed as reduction in TNF-alpha release after 10 mins by ELISA				J Med Chem 60: 8027-8054 (2017) Article DOI: 10.1021/acs.jmedchem.7b00745 BindingDB Entry DOI: 10.7270/Q2RV0QVZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50241024 (CHEMBL4076950) Show SMILES Fc1cc(F)c(Nc2ccc3c(OCc4ccc(cc4C3=O)C(=O)NCCN3CCOCC3)c2)cc1NC(=O)c1cccs1 Show InChI InChI=1S/C32H28F2N4O5S/c33-24-16-25(34)27(37-32(41)29-2-1-13-44-29)17-26(24)36-21-5-6-22-28(15-21)43-18-20-4-3-19(14-23(20)30(22)39)31(40)35-7-8-38-9-11-42-12-10-38/h1-6,13-17,36H,7-12,18H2,(H,35,40)(H,37,41)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Eberhard-Karls-Universitaet Tuebingen Curated by ChEMBL					Assay Description Inhibition of P38 alpha MAPK (unknown origin) by ELISA				J Med Chem 60: 8027-8054 (2017) Article DOI: 10.1021/acs.jmedchem.7b00745 BindingDB Entry DOI: 10.7270/Q2RV0QVZ
					More data for this Ligand-Target Pair