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SMILES: FC(F)(F)c1cc(N\N=C(/C#N)C(=O)c2cc(on2)-c2ccc(Cl)cc2)ccc1Cl

InChI Key: InChIKey=AFBVEEXDEIFPKO-JVWAILMASA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50241964   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Rap guanine nucleotide exchange factor 3


(Homo sapiens (Human))		BDBM50241964
PNG
(CHEMBL4074930)
Show SMILES FC(F)(F)c1cc(N\N=C(/C#N)C(=O)c2cc(on2)-c2ccc(Cl)cc2)ccc1Cl
Show InChI InChI=1S/C19H9Cl2F3N4O2/c20-11-3-1-10(2-4-11)17-8-15(28-30-17)18(29)16(9-25)27-26-12-5-6-14(21)13(7-12)19(22,23)24/h1-8,26H/b27-16+
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Article
PubMed
n/an/a 7.80E+3n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human full length EPAC1 assessed as inhibition of EPAC1-mediated Rap1B (1 to 167 residues)-BODIPY GDP nucleotide e...

Eur J Med Chem 134: 62-71 (2017)


Article DOI: 10.1016/j.ejmech.2017.04.001
BindingDB Entry DOI: 10.7270/Q2RR21DK
More data for this
Ligand-Target Pair