BDBM50241965 CHEMBL4093887

SMILES: Clc1ccc(cc1)-c1cc(no1)C(=O)C(=N\Nc1cccc(Cl)c1)\C#N

InChI Key: InChIKey=DKZIBEPCWDPRMI-XQNSMLJCSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50241965   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rap guanine nucleotide exchange factor 3 (Homo sapiens (Human))	BDBM50241965 (CHEMBL4093887) Show SMILES Clc1ccc(cc1)-c1cc(no1)C(=O)C(=N\Nc1cccc(Cl)c1)\C#N Show InChI InChI=1S/C18H10Cl2N4O2/c19-12-6-4-11(5-7-12)17-9-15(24-26-17)18(25)16(10-21)23-22-14-3-1-2-13(20)8-14/h1-9,22H/b23-16+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7.76E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Antagonist activity at recombinant human full length EPAC1 assessed as inhibition of EPAC1-mediated Rap1B (1 to 167 residues)-BODIPY GDP nucleotide e...				Eur J Med Chem 134: 62-71 (2017) Article DOI: 10.1016/j.ejmech.2017.04.001 BindingDB Entry DOI: 10.7270/Q2RR21DK
					More data for this Ligand-Target Pair