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SMILES: Fc1ccc(cc1)-c1cc(no1)C(=O)C(=N\Nc1cc(Cl)cc(c1)C(F)(F)F)\C#N

InChI Key: InChIKey=CLKIYKLNZSHXSS-JVWAILMASA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50241972   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Rap guanine nucleotide exchange factor 3


(Homo sapiens (Human))		BDBM50241972
PNG
(CHEMBL4102135)
Show SMILES Fc1ccc(cc1)-c1cc(no1)C(=O)C(=N\Nc1cc(Cl)cc(c1)C(F)(F)F)\C#N
Show InChI InChI=1S/C19H9ClF4N4O2/c20-12-5-11(19(22,23)24)6-14(7-12)26-27-16(9-25)18(29)15-8-17(30-28-15)10-1-3-13(21)4-2-10/h1-8,26H/b27-16+
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Similars
Article
PubMed
n/an/a 1.27E+4n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human full length EPAC1 assessed as inhibition of EPAC1-mediated Rap1B (1 to 167 residues)-BODIPY GDP nucleotide e...

Eur J Med Chem 134: 62-71 (2017)


Article DOI: 10.1016/j.ejmech.2017.04.001
BindingDB Entry DOI: 10.7270/Q2RR21DK
More data for this
Ligand-Target Pair