BDBM50243762 2-(3,3-difluoropyrrolidin-1-yl)-6-phenyl-7-(4-((4-(5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)piperidin-1-yl)methyl)phenyl)pyrido[2,3-d]pyrimidine::CHEMBL451961

SMILES: FC1(F)CCN(C1)c1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)c2nnc([nH]2)-c2ccccn2)cc1

InChI Key: InChIKey=PXLDHSKDCUXBTE-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50243762   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase AKT2 (Homo sapiens (Human))	BDBM50243762 (2-(3,3-difluoropyrrolidin-1-yl)-6-phenyl-7-(4-((4-...) Show SMILES FC1(F)CCN(C1)c1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)c2nnc([nH]2)-c2ccccn2)cc1 Show InChI InChI=1S/C36H33F2N9/c37-36(38)15-19-47(23-36)35-40-21-28-20-29(25-6-2-1-3-7-25)31(41-32(28)43-35)26-11-9-24(10-12-26)22-46-17-13-27(14-18-46)33-42-34(45-44-33)30-8-4-5-16-39-30/h1-12,16,20-21,27H,13-15,17-19,22-23H2,(H,42,44,45)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	252	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Akt2 (unknown origin) phosphorylation by HTRF assay				Bioorg Med Chem Lett 18: 4186-90 (2008) Article DOI: 10.1016/j.bmcl.2008.05.085 BindingDB Entry DOI: 10.7270/Q2F76CBC
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase AKT2 (Homo sapiens (Human))	BDBM50243762 (2-(3,3-difluoropyrrolidin-1-yl)-6-phenyl-7-(4-((4-...) Show SMILES FC1(F)CCN(C1)c1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)c2nnc([nH]2)-c2ccccn2)cc1 Show InChI InChI=1S/C36H33F2N9/c37-36(38)15-19-47(23-36)35-40-21-28-20-29(25-6-2-1-3-7-25)31(41-32(28)43-35)26-11-9-24(10-12-26)22-46-17-13-27(14-18-46)33-42-34(45-44-33)30-8-4-5-16-39-30/h1-12,16,20-21,27H,13-15,17-19,22-23H2,(H,42,44,45)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	462	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Akt2 (unknown origin) phosphorylation in human by C33a cells by IPKA assay				Bioorg Med Chem Lett 18: 4186-90 (2008) Article DOI: 10.1016/j.bmcl.2008.05.085 BindingDB Entry DOI: 10.7270/Q2F76CBC
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50243762 (2-(3,3-difluoropyrrolidin-1-yl)-6-phenyl-7-(4-((4-...) Show SMILES FC1(F)CCN(C1)c1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)c2nnc([nH]2)-c2ccccn2)cc1 Show InChI InChI=1S/C36H33F2N9/c37-36(38)15-19-47(23-36)35-40-21-28-20-29(25-6-2-1-3-7-25)31(41-32(28)43-35)26-11-9-24(10-12-26)22-46-17-13-27(14-18-46)33-42-34(45-44-33)30-8-4-5-16-39-30/h1-12,16,20-21,27H,13-15,17-19,22-23H2,(H,42,44,45)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Akt1 (unknown origin) phosphorylation by HTRF assay				Bioorg Med Chem Lett 18: 4186-90 (2008) Article DOI: 10.1016/j.bmcl.2008.05.085 BindingDB Entry DOI: 10.7270/Q2F76CBC
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50243762 (2-(3,3-difluoropyrrolidin-1-yl)-6-phenyl-7-(4-((4-...) Show SMILES FC1(F)CCN(C1)c1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)c2nnc([nH]2)-c2ccccn2)cc1 Show InChI InChI=1S/C36H33F2N9/c37-36(38)15-19-47(23-36)35-40-21-28-20-29(25-6-2-1-3-7-25)31(41-32(28)43-35)26-11-9-24(10-12-26)22-46-17-13-27(14-18-46)33-42-34(45-44-33)30-8-4-5-16-39-30/h1-12,16,20-21,27H,13-15,17-19,22-23H2,(H,42,44,45)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	75	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Akt1 (unknown origin) phosphorylation in human by C33a cells by IPKA assay				Bioorg Med Chem Lett 18: 4186-90 (2008) Article DOI: 10.1016/j.bmcl.2008.05.085 BindingDB Entry DOI: 10.7270/Q2F76CBC
					More data for this Ligand-Target Pair