BDBM50243766 2-((2S,6R)-2,6-dimethylmorpholino)-6-phenyl-7-(4-((4-(5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)piperidin-1-yl)methyl)phenyl)pyrido[2,3-d]pyrimidine::CHEMBL448826

SMILES: C[C@H]1CN(C[C@@H](C)O1)c1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)c2nnc([nH]2)-c2ccccn2)cc1

InChI Key: InChIKey=ZOAZOJRIZYTSSL-WMPKNSHKSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50243766   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase AKT2 (Homo sapiens (Human))	BDBM50243766 (2-((2S,6R)-2,6-dimethylmorpholino)-6-phenyl-7-(4-(...) Show SMILES C[C@H]1CN(C[C@@H](C)O1)c1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)c2nnc([nH]2)-c2ccccn2)cc1 |r| Show InChI InChI=1S/C38H39N9O/c1-25-22-47(23-26(2)48-25)38-40-21-31-20-32(28-8-4-3-5-9-28)34(41-35(31)43-38)29-13-11-27(12-14-29)24-46-18-15-30(16-19-46)36-42-37(45-44-36)33-10-6-7-17-39-33/h3-14,17,20-21,25-26,30H,15-16,18-19,22-24H2,1-2H3,(H,42,44,45)/t25-,26+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	102	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Akt2 (unknown origin) phosphorylation by HTRF assay				Bioorg Med Chem Lett 18: 4186-90 (2008) Article DOI: 10.1016/j.bmcl.2008.05.085 BindingDB Entry DOI: 10.7270/Q2F76CBC
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase AKT2 (Homo sapiens (Human))	BDBM50243766 (2-((2S,6R)-2,6-dimethylmorpholino)-6-phenyl-7-(4-(...) Show SMILES C[C@H]1CN(C[C@@H](C)O1)c1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)c2nnc([nH]2)-c2ccccn2)cc1 |r| Show InChI InChI=1S/C38H39N9O/c1-25-22-47(23-26(2)48-25)38-40-21-31-20-32(28-8-4-3-5-9-28)34(41-35(31)43-38)29-13-11-27(12-14-29)24-46-18-15-30(16-19-46)36-42-37(45-44-36)33-10-6-7-17-39-33/h3-14,17,20-21,25-26,30H,15-16,18-19,22-24H2,1-2H3,(H,42,44,45)/t25-,26+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	184	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Akt2 (unknown origin) phosphorylation in human by C33a cells by IPKA assay				Bioorg Med Chem Lett 18: 4186-90 (2008) Article DOI: 10.1016/j.bmcl.2008.05.085 BindingDB Entry DOI: 10.7270/Q2F76CBC
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50243766 (2-((2S,6R)-2,6-dimethylmorpholino)-6-phenyl-7-(4-(...) Show SMILES C[C@H]1CN(C[C@@H](C)O1)c1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)c2nnc([nH]2)-c2ccccn2)cc1 |r| Show InChI InChI=1S/C38H39N9O/c1-25-22-47(23-26(2)48-25)38-40-21-31-20-32(28-8-4-3-5-9-28)34(41-35(31)43-38)29-13-11-27(12-14-29)24-46-18-15-30(16-19-46)36-42-37(45-44-36)33-10-6-7-17-39-33/h3-14,17,20-21,25-26,30H,15-16,18-19,22-24H2,1-2H3,(H,42,44,45)/t25-,26+	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Akt1 (unknown origin) phosphorylation by HTRF assay				Bioorg Med Chem Lett 18: 4186-90 (2008) Article DOI: 10.1016/j.bmcl.2008.05.085 BindingDB Entry DOI: 10.7270/Q2F76CBC
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50243766 (2-((2S,6R)-2,6-dimethylmorpholino)-6-phenyl-7-(4-(...) Show SMILES C[C@H]1CN(C[C@@H](C)O1)c1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)c2nnc([nH]2)-c2ccccn2)cc1 |r| Show InChI InChI=1S/C38H39N9O/c1-25-22-47(23-26(2)48-25)38-40-21-31-20-32(28-8-4-3-5-9-28)34(41-35(31)43-38)29-13-11-27(12-14-29)24-46-18-15-30(16-19-46)36-42-37(45-44-36)33-10-6-7-17-39-33/h3-14,17,20-21,25-26,30H,15-16,18-19,22-24H2,1-2H3,(H,42,44,45)/t25-,26+	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Akt1 (unknown origin) phosphorylation in human by C33a cells by IPKA assay				Bioorg Med Chem Lett 18: 4186-90 (2008) Article DOI: 10.1016/j.bmcl.2008.05.085 BindingDB Entry DOI: 10.7270/Q2F76CBC
					More data for this Ligand-Target Pair