BDBM50243771 2-(4-methylpiperazin-1-yl)-6-phenyl-7-(4-((4-(5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)piperidin-1-yl)methyl)phenyl)pyrido[2,3-d]pyrimidine::CHEMBL504251

SMILES: CN1CCN(CC1)c1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)c2nnc([nH]2)-c2ccccn2)cc1

InChI Key: InChIKey=JXLMTKNUQUEKTP-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50243771   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase AKT2 (Homo sapiens (Human))	BDBM50243771 (2-(4-methylpiperazin-1-yl)-6-phenyl-7-(4-((4-(5-(p...) Show SMILES CN1CCN(CC1)c1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)c2nnc([nH]2)-c2ccccn2)cc1 Show InChI InChI=1S/C37H38N10/c1-45-19-21-47(22-20-45)37-39-24-30-23-31(27-7-3-2-4-8-27)33(40-34(30)42-37)28-12-10-26(11-13-28)25-46-17-14-29(15-18-46)35-41-36(44-43-35)32-9-5-6-16-38-32/h2-13,16,23-24,29H,14-15,17-22,25H2,1H3,(H,41,43,44)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Akt2 (unknown origin) phosphorylation by HTRF assay				Bioorg Med Chem Lett 18: 4186-90 (2008) Article DOI: 10.1016/j.bmcl.2008.05.085 BindingDB Entry DOI: 10.7270/Q2F76CBC
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase AKT2 (Homo sapiens (Human))	BDBM50243771 (2-(4-methylpiperazin-1-yl)-6-phenyl-7-(4-((4-(5-(p...) Show SMILES CN1CCN(CC1)c1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)c2nnc([nH]2)-c2ccccn2)cc1 Show InChI InChI=1S/C37H38N10/c1-45-19-21-47(22-20-45)37-39-24-30-23-31(27-7-3-2-4-8-27)33(40-34(30)42-37)28-12-10-26(11-13-28)25-46-17-14-29(15-18-46)35-41-36(44-43-35)32-9-5-6-16-38-32/h2-13,16,23-24,29H,14-15,17-22,25H2,1H3,(H,41,43,44)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	52	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Akt2 (unknown origin) phosphorylation in human by C33a cells by IPKA assay				Bioorg Med Chem Lett 18: 4186-90 (2008) Article DOI: 10.1016/j.bmcl.2008.05.085 BindingDB Entry DOI: 10.7270/Q2F76CBC
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50243771 (2-(4-methylpiperazin-1-yl)-6-phenyl-7-(4-((4-(5-(p...) Show SMILES CN1CCN(CC1)c1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)c2nnc([nH]2)-c2ccccn2)cc1 Show InChI InChI=1S/C37H38N10/c1-45-19-21-47(22-20-45)37-39-24-30-23-31(27-7-3-2-4-8-27)33(40-34(30)42-37)28-12-10-26(11-13-28)25-46-17-14-29(15-18-46)35-41-36(44-43-35)32-9-5-6-16-38-32/h2-13,16,23-24,29H,14-15,17-22,25H2,1H3,(H,41,43,44)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Akt1 (unknown origin) phosphorylation by HTRF assay				Bioorg Med Chem Lett 18: 4186-90 (2008) Article DOI: 10.1016/j.bmcl.2008.05.085 BindingDB Entry DOI: 10.7270/Q2F76CBC
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50243771 (2-(4-methylpiperazin-1-yl)-6-phenyl-7-(4-((4-(5-(p...) Show SMILES CN1CCN(CC1)c1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)c2nnc([nH]2)-c2ccccn2)cc1 Show InChI InChI=1S/C37H38N10/c1-45-19-21-47(22-20-45)37-39-24-30-23-31(27-7-3-2-4-8-27)33(40-34(30)42-37)28-12-10-26(11-13-28)25-46-17-14-29(15-18-46)35-41-36(44-43-35)32-9-5-6-16-38-32/h2-13,16,23-24,29H,14-15,17-22,25H2,1H3,(H,41,43,44)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Akt1 (unknown origin) phosphorylation in human by C33a cells by IPKA assay				Bioorg Med Chem Lett 18: 4186-90 (2008) Article DOI: 10.1016/j.bmcl.2008.05.085 BindingDB Entry DOI: 10.7270/Q2F76CBC
					More data for this Ligand-Target Pair