BDBM50243781 2-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-6-phenyl-7-(4-((4-(5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)piperidin-1-yl)methyl)phenyl)pyrido[2,3-d]pyrimidine::CHEMBL447044

SMILES: C(N1CCC(CC1)c1nnc([nH]1)-c1ccccn1)c1ccc(cc1)-c1nc2nc(ncc2cc1-c1ccccc1)N1CCn2cnnc2C1

InChI Key: InChIKey=CLGHRVKBVKFOQI-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50243781   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase AKT2 (Homo sapiens (Human))	BDBM50243781 (2-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)...) Show SMILES C(N1CCC(CC1)c1nnc([nH]1)-c1ccccn1)c1ccc(cc1)-c1nc2nc(ncc2cc1-c1ccccc1)N1CCn2cnnc2C1 Show InChI InChI=1S/C37H34N12/c1-2-6-26(7-3-1)30-20-29-21-39-37(48-18-19-49-24-40-44-32(49)23-48)43-34(29)41-33(30)27-11-9-25(10-12-27)22-47-16-13-28(14-17-47)35-42-36(46-45-35)31-8-4-5-15-38-31/h1-12,15,20-21,24,28H,13-14,16-19,22-23H2,(H,42,45,46)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	138	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Akt2 (unknown origin) phosphorylation by HTRF assay				Bioorg Med Chem Lett 18: 4186-90 (2008) Article DOI: 10.1016/j.bmcl.2008.05.085 BindingDB Entry DOI: 10.7270/Q2F76CBC
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50243781 (2-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)...) Show SMILES C(N1CCC(CC1)c1nnc([nH]1)-c1ccccn1)c1ccc(cc1)-c1nc2nc(ncc2cc1-c1ccccc1)N1CCn2cnnc2C1 Show InChI InChI=1S/C37H34N12/c1-2-6-26(7-3-1)30-20-29-21-39-37(48-18-19-49-24-40-44-32(49)23-48)43-34(29)41-33(30)27-11-9-25(10-12-27)22-47-16-13-28(14-17-47)35-42-36(46-45-35)31-8-4-5-15-38-31/h1-12,15,20-21,24,28H,13-14,16-19,22-23H2,(H,42,45,46)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Akt1 (unknown origin) phosphorylation by HTRF assay				Bioorg Med Chem Lett 18: 4186-90 (2008) Article DOI: 10.1016/j.bmcl.2008.05.085 BindingDB Entry DOI: 10.7270/Q2F76CBC
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase AKT2 (Homo sapiens (Human))	BDBM50243781 (2-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)...) Show SMILES C(N1CCC(CC1)c1nnc([nH]1)-c1ccccn1)c1ccc(cc1)-c1nc2nc(ncc2cc1-c1ccccc1)N1CCn2cnnc2C1 Show InChI InChI=1S/C37H34N12/c1-2-6-26(7-3-1)30-20-29-21-39-37(48-18-19-49-24-40-44-32(49)23-48)43-34(29)41-33(30)27-11-9-25(10-12-27)22-47-16-13-28(14-17-47)35-42-36(46-45-35)31-8-4-5-15-38-31/h1-12,15,20-21,24,28H,13-14,16-19,22-23H2,(H,42,45,46)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	735	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Akt2 (unknown origin) phosphorylation in human by C33a cells by IPKA assay				Bioorg Med Chem Lett 18: 4186-90 (2008) Article DOI: 10.1016/j.bmcl.2008.05.085 BindingDB Entry DOI: 10.7270/Q2F76CBC
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50243781 (2-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)...) Show SMILES C(N1CCC(CC1)c1nnc([nH]1)-c1ccccn1)c1ccc(cc1)-c1nc2nc(ncc2cc1-c1ccccc1)N1CCn2cnnc2C1 Show InChI InChI=1S/C37H34N12/c1-2-6-26(7-3-1)30-20-29-21-39-37(48-18-19-49-24-40-44-32(49)23-48)43-34(29)41-33(30)27-11-9-25(10-12-27)22-47-16-13-28(14-17-47)35-42-36(46-45-35)31-8-4-5-15-38-31/h1-12,15,20-21,24,28H,13-14,16-19,22-23H2,(H,42,45,46)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	125	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Akt1 (unknown origin) phosphorylation in human by C33a cells by IPKA assay				Bioorg Med Chem Lett 18: 4186-90 (2008) Article DOI: 10.1016/j.bmcl.2008.05.085 BindingDB Entry DOI: 10.7270/Q2F76CBC
					More data for this Ligand-Target Pair