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BDBM50244732 6-(4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)-5-nitro-N-(4-(propylsulfonyl)phenyl)-pyrimidin-4-amine::CHEMBL461558

SMILES: CCCS(=O)(=O)c1ccc(Nc2ncnc(N3CCC(CC3)c3nc([n-][o+]3)C(C)C)c2[N+]([O-])=O)cc1

InChI Key: InChIKey=FTXDUXBGXXFBLF-UHFFFAOYSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50244732   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))		BDBM50244732
PNG
(6-(4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1...)
Show SMILES CCCS(=O)(=O)c1ccc(Nc2ncnc(N3CCC(CC3)c3nc([n-][o+]3)C(C)C)c2[N+]([O-])=O)cc1
Show InChI InChI=1S/C23H29N7O5S/c1-4-13-36(33,34)18-7-5-17(6-8-18)26-21-19(30(31)32)22(25-14-24-21)29-11-9-16(10-12-29)23-27-20(15(2)3)28-35-23/h5-8,14-16H,4,9-13H2,1-3H3,(H,24,25,26)
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Similars
Article
PubMed
n/an/an/an/a 4.70n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at CPR119 (unknown origin) transfected in Xenopus dermal melanophore assessed as dispersion of melatonin-induced pigmentation

J Med Chem 51: 5172-5 (2008)


Article DOI: 10.1021/jm8006867
BindingDB Entry DOI: 10.7270/Q2KW5FVB
More data for this
Ligand-Target Pair