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BDBM50244733 6-(4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)-N-(4-(isopropylsulfonyl)phenyl)-5-nitropyrimidin-4-amine::CHEMBL461747

SMILES: CC(C)c1nc([o+][n-]1)C1CCN(CC1)c1ncnc(Nc2ccc(cc2)S(=O)(=O)C(C)C)c1[N+]([O-])=O

InChI Key: InChIKey=QTBSMZUWNKCUQV-UHFFFAOYSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50244733   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))		BDBM50244733
PNG
(6-(4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1...)
Show SMILES CC(C)c1nc([o+][n-]1)C1CCN(CC1)c1ncnc(Nc2ccc(cc2)S(=O)(=O)C(C)C)c1[N+]([O-])=O
Show InChI InChI=1S/C23H29N7O5S/c1-14(2)20-27-23(35-28-20)16-9-11-29(12-10-16)22-19(30(31)32)21(24-13-25-22)26-17-5-7-18(8-6-17)36(33,34)15(3)4/h5-8,13-16H,9-12H2,1-4H3,(H,24,25,26)
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Similars
Article
PubMed
n/an/an/an/a 7.80n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at CPR119 (unknown origin) transfected in Xenopus dermal melanophore assessed as dispersion of melatonin-induced pigmentation

J Med Chem 51: 5172-5 (2008)


Article DOI: 10.1021/jm8006867
BindingDB Entry DOI: 10.7270/Q2KW5FVB
More data for this
Ligand-Target Pair