BDBM50246200 CHEMBL487247::N-(4-(3-chloro-4-methoxybenzylamino)-8-(2-hydroxyethyl)-7-methoxyquinazolin-6-yl)picolinamide

SMILES: COc1ccc(CNc2ncnc3c(CCO)c(OC)c(NC(=O)c4ccccn4)cc23)cc1Cl

InChI Key: InChIKey=OSVFHFSXQMNPLN-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50246200   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphodiesterase 5A (Bos taurus)	BDBM50246200 (CHEMBL487247 | N-(4-(3-chloro-4-methoxybenzylamino...) Show SMILES COc1ccc(CNc2ncnc3c(CCO)c(OC)c(NC(=O)c4ccccn4)cc23)cc1Cl Show InChI InChI=1S/C25H24ClN5O4/c1-34-21-7-6-15(11-18(21)26)13-28-24-17-12-20(31-25(33)19-5-3-4-9-27-19)23(35-2)16(8-10-32)22(17)29-14-30-24/h3-7,9,11-12,14,32H,8,10,13H2,1-2H3,(H,31,33)(H,28,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chong Kun Dang Research Institute Curated by ChEMBL					Assay Description Inhibition of bovine PDE5				Bioorg Med Chem Lett 18: 6279-82 (2008) Article DOI: 10.1016/j.bmcl.2008.09.108 BindingDB Entry DOI: 10.7270/Q2SB45MV
					More data for this Ligand-Target Pair