BDBM50246816 1,3-Bis(3-(4-(2-(pyrrolidin-1-yl)acetamido)phenylcarbamoyl)phenyl)urea::CHEMBL508572

SMILES: O=C(CN1CCCC1)Nc1ccc(NC(=O)c2cccc(NC(=O)Nc3cccc(c3)C(=O)Nc3ccc(NC(=O)CN4CCCC4)cc3)c2)cc1

InChI Key: InChIKey=CROYNBMTRRPDSN-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50246816   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50246816 (1,3-Bis(3-(4-(2-(pyrrolidin-1-yl)acetamido)phenylc...) Show SMILES O=C(CN1CCCC1)Nc1ccc(NC(=O)c2cccc(NC(=O)Nc3cccc(c3)C(=O)Nc3ccc(NC(=O)CN4CCCC4)cc3)c2)cc1 Show InChI InChI=1S/C39H42N8O5/c48-35(25-46-19-1-2-20-46)40-29-11-15-31(16-12-29)42-37(50)27-7-5-9-33(23-27)44-39(52)45-34-10-6-8-28(24-34)38(51)43-32-17-13-30(14-18-32)41-36(49)26-47-21-3-4-22-47/h5-18,23-24H,1-4,19-22,25-26H2,(H,40,48)(H,41,49)(H,42,50)(H,43,51)(H2,44,45,52)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a
University of London Curated by ChEMBL					Assay Description Inhibition of telomerase (unknown origin) by TRAP-LIG assay				J Med Chem 51: 7751-67 (2008) Article DOI: 10.1021/jm801245v BindingDB Entry DOI: 10.7270/Q2CN73SS
					More data for this Ligand-Target Pair