Found 3 hits for monomerid = 50248567 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50248567
(1-(((3R)-3-methyl-4-(4-(1,1,1-trifluoro-2-hydroxyp...)Show SMILES C[C@@H]1CN(CC2(CCC2)C(N)=O)CCN1S(=O)(=O)c1ccc(cc1)C(C)(O)C(F)(F)F |r| Show InChI InChI=1S/C20H28F3N3O4S/c1-14-12-25(13-19(17(24)27)8-3-9-19)10-11-26(14)31(29,30)16-6-4-15(5-7-16)18(2,28)20(21,22)23/h4-7,14,28H,3,8-13H2,1-2H3,(H2,24,27)/t14-,18?/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 6.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of human ERG by patch clamp technique |
Bioorg Med Chem Lett 19: 1522-7 (2009)
Article DOI: 10.1016/j.bmcl.2008.12.114 BindingDB Entry DOI: 10.7270/Q2QC03BN |
More data for this Ligand-Target Pair | |
Cytochrome P450 3A4
(Homo sapiens (Human)) | BDBM50248567
(1-(((3R)-3-methyl-4-(4-(1,1,1-trifluoro-2-hydroxyp...)Show SMILES C[C@@H]1CN(CC2(CCC2)C(N)=O)CCN1S(=O)(=O)c1ccc(cc1)C(C)(O)C(F)(F)F |r| Show InChI InChI=1S/C20H28F3N3O4S/c1-14-12-25(13-19(17(24)27)8-3-9-19)10-11-26(14)31(29,30)16-6-4-15(5-7-16)18(2,28)20(21,22)23/h4-7,14,28H,3,8-13H2,1-2H3,(H2,24,27)/t14-,18?/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 6.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of CYP3A4 (unknown origin) |
Bioorg Med Chem Lett 19: 1522-7 (2009)
Article DOI: 10.1016/j.bmcl.2008.12.114 BindingDB Entry DOI: 10.7270/Q2QC03BN |
More data for this Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50248567
(1-(((3R)-3-methyl-4-(4-(1,1,1-trifluoro-2-hydroxyp...)Show SMILES C[C@@H]1CN(CC2(CCC2)C(N)=O)CCN1S(=O)(=O)c1ccc(cc1)C(C)(O)C(F)(F)F |r| Show InChI InChI=1S/C20H28F3N3O4S/c1-14-12-25(13-19(17(24)27)8-3-9-19)10-11-26(14)31(29,30)16-6-4-15(5-7-16)18(2,28)20(21,22)23/h4-7,14,28H,3,8-13H2,1-2H3,(H2,24,27)/t14-,18?/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of full length human recombinant 11beta-HSD1 expressed in baculovirus insect cell system assessed as conversion of [3H]cortisone to [3H]co... |
Bioorg Med Chem Lett 19: 1522-7 (2009)
Article DOI: 10.1016/j.bmcl.2008.12.114 BindingDB Entry DOI: 10.7270/Q2QC03BN |
More data for this Ligand-Target Pair | |