BDBM50249081 CHEMBL452136::N'-(2,4-dihydroxy-6-methylbenzylidene)-2-(m-tolyloxy)acetohydrazide

SMILES: Cc1cccc(OCC(=O)NN=Cc2c(C)cc(O)cc2O)c1

InChI Key: InChIKey=RFVLEYAFCOXWIM-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50249081   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Mus musculus (mouse))	BDBM50249081 (CHEMBL452136 | N'-(2,4-dihydroxy-6-methylbenzylide...) Show SMILES Cc1cccc(OCC(=O)NN=Cc2c(C)cc(O)cc2O)c1 |w:11.10| Show InChI InChI=1S/C17H18N2O4/c1-11-4-3-5-14(6-11)23-10-17(22)19-18-9-15-12(2)7-13(20)8-16(15)21/h3-9,20-21H,10H2,1-2H3,(H,19,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Materia Medica Curated by ChEMBL					Assay Description Inhibition of mouse 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay in...				Eur J Med Chem 44: 1167-71 (2009) Article DOI: 10.1016/j.ejmech.2008.06.005 BindingDB Entry DOI: 10.7270/Q2251J0Z
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50249081 (CHEMBL452136 | N'-(2,4-dihydroxy-6-methylbenzylide...) Show SMILES Cc1cccc(OCC(=O)NN=Cc2c(C)cc(O)cc2O)c1 |w:11.10| Show InChI InChI=1S/C17H18N2O4/c1-11-4-3-5-14(6-11)23-10-17(22)19-18-9-15-12(2)7-13(20)8-16(15)21/h3-9,20-21H,10H2,1-2H3,(H,19,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.09E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Materia Medica Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay in...				Eur J Med Chem 44: 1167-71 (2009) Article DOI: 10.1016/j.ejmech.2008.06.005 BindingDB Entry DOI: 10.7270/Q2251J0Z
					More data for this Ligand-Target Pair