BDBM50249452 2-(2-aminoethylamino)-4-(p-tolylamino)pyrimidine-5-carboxamide::CHEMBL475371

SMILES: Cc1ccc(Nc2nc(NCCN)ncc2C(N)=O)cc1

InChI Key: InChIKey=PHHCDYHRFLEBMR-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50249452   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50249452 (2-(2-aminoethylamino)-4-(p-tolylamino)pyrimidine-5...) Show SMILES Cc1ccc(Nc2nc(NCCN)ncc2C(N)=O)cc1 Show InChI InChI=1S/C14H18N6O/c1-9-2-4-10(5-3-9)19-13-11(12(16)21)8-18-14(20-13)17-7-6-15/h2-5,8H,6-7,15H2,1H3,(H2,16,21)(H2,17,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of recombinant Syk (unknown origin)				Bioorg Med Chem Lett 19: 1944-9 (2009) Article DOI: 10.1016/j.bmcl.2009.02.049 BindingDB Entry DOI: 10.7270/Q2WM1D98
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50249452 (2-(2-aminoethylamino)-4-(p-tolylamino)pyrimidine-5...) Show SMILES Cc1ccc(Nc2nc(NCCN)ncc2C(N)=O)cc1 Show InChI InChI=1S/C14H18N6O/c1-9-2-4-10(5-3-9)19-13-11(12(16)21)8-18-14(20-13)17-7-6-15/h2-5,8H,6-7,15H2,1H3,(H2,16,21)(H2,17,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
Punjabi University Curated by ChEMBL					Assay Description Inhibition of spleen tyrosine kinase (unknown origin)				Eur J Med Chem 67: 434-46 (2013) Article DOI: 10.1016/j.ejmech.2013.04.070 BindingDB Entry DOI: 10.7270/Q2Z039JB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM50249452 (2-(2-aminoethylamino)-4-(p-tolylamino)pyrimidine-5...) Show SMILES Cc1ccc(Nc2nc(NCCN)ncc2C(N)=O)cc1 Show InChI InChI=1S/C14H18N6O/c1-9-2-4-10(5-3-9)19-13-11(12(16)21)8-18-14(20-13)17-7-6-15/h2-5,8H,6-7,15H2,1H3,(H2,16,21)(H2,17,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
GVK Biosciences Pvt. Ltd. Curated by ChEMBL					Assay Description Inhibition of human GST-fused ZAP-70 expressed in Sf9 cells				Eur J Med Chem 44: 4793-800 (2009) Article DOI: 10.1016/j.ejmech.2009.07.018 BindingDB Entry DOI: 10.7270/Q25X290Z
					More data for this Ligand-Target Pair